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Amylase, a-, Aspergillus oryzae CAS:9001-19-8 Igiciro cy'umukozi
AmYlase ni enzyme yoroshya ivunjwa rya sitashi rigahinduka isukari yoroshye nka maltose na glucose. Ikunze gukorwa n'ibinyabuzima bitandukanye, harimo bagiteri, fungi n'ibimera.
"a-" muri "a-amylase" yerekeza ku bwoko bwa amylase butuma by'umwihariko imigozi ya alpha-1,4 glycosidic iri mu ngirabuzimafatizo ya sitashi ikorwa. Ibi bituma habaho polysaccharides ngufi, zishobora gucibwamo glucose n'izindi enzymes za amylase.
Aspergillus oryzae ni ubwoko bw'ibihumyo bifite uduce duto bizwiho ubushobozi bwo gukora amylase nyinshi. Ikunze gukoreshwa mu gukora enzymes mu nganda bitewe n'imikorere yayo ikomeye ya amylolytic. Enzymes zikorwa na Aspergillus oryzae, harimo na a-amylase, zikoreshwa cyane mu nganda zitandukanye, nko mu biribwa, mu guteka, mu myenda no mu nganda zikora isuku.
Mu nganda z'ibiribwa, a-amylase ikomoka kuri Aspergillus oryzae ikunze gukoreshwa mu guteka, guteka no gutunganya asheri. Ifasha mu gusenya asheri mu ifu, uburo n'ibindi bikoresho fatizo, byoroshya guhindura karubohidrati zikomeye mo isukari yoroshye ishobora guhindurwamo umusemburo cyangwa bagiteri mu gihe cyo guhinga. Iyi enzyme ikoreshwa kandi mu nganda z'imyenda kugira ngo yorohereze gukuraho ibipimo bishingiye kuri asheri mu myenda.
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Aprotinine CAS: 9087-70-1 Igiciro cy'umukozi
Aprotinin ni poroteyine ikoreshwa mu buryo karemano mu gukumira enzymes zitandukanye zirwanya poroteyine, harimo trypsin, chymotrypsin, na plasmine. Ikunze gukoreshwa mu buvuzi, cyane cyane mu kubaga indwara z'umutima n'imitsi, kugira ngo igabanye kuva amaraso no kugabanya gutakaza amaraso. Aprotinin ikora mu kubuza imikorere y'izi enzymes, zigira uruhare mu gusenyuka kw'amaraso no kwangirika kwa fibrin, poroteyine ifasha mu kurema ibice by'amaraso. Mu gukumira imikorere myinshi ya enzymes, aprotinin ifasha mu kubungabunga imiterere y'amaraso, bityo ikagabanya ingorane zo kuva amaraso mu gihe cyo kubagwa.
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Thrombin CAS:9002-04-4 Igiciro cy'umukozi
Thrombin ni enzyme y'ingenzi igira uruhare mu gutuma amaraso agwa, izwi kandi nka "coagulation". Ikorwa muri poroteyine yayo ya mbere, prothrombin, mu rwego rwo guhangana n'ibyago cyangwa kwangirika kw'imitsi y'amaraso. Thrombin igira uruhare runini mu gutuma amaraso agwa, ibi bifasha mu gukumira kuva amaraso menshi no gukira ibikomere.
Iyo imaze gukora, thrombin ihindura fibrinogen, indi poroteyine iri mu maraso, fibrin. Fibrin ikora imiterere isa n'iy'urushundura ifata platelets n'uturemangingo dutukura tw'amaraso, bigatuma amaraso ahinduka nk'aho adahinduka. Thrombin kandi ikora izindi factors zo gufungana kw'amaraso, yongera uburyo bwo kuvura amaraso.
Uretse uruhare rwayo mu kurema ibice by'umubiri, thrombin ifite indi mirimo y'ingenzi. Ifasha mu gukira kw'ibikomere binyuze mu gutuma uturemangingo dufasha mu gusana ingirabuzimafatizo no kwiyongera kw'uturemangingo. Thrombin kandi ikora nk'umuti ugabanya imitsi, bigatuma imiyoboro y'amaraso ifungana kandi ikagabanya amaraso atembera aho yakomeretse.
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Urease CAS: 9002-13-5 Igiciro cy'umukozi
Urease ni enzyme ihindura hydrolysis ya urea ikayihindura ammonia na dioxyde de carbone. Ikorwa n'udukoko duto dutandukanye, harimo bagiteri, ibihumyo, n'ibimera. Urease ni ingenzi mu mikorere ya azote kandi igira uruhare runini mu mikorere itandukanye ya biyoloji, nko guhinda urea mu mpyiko no kwinjira kwa azote mu bimera. Ifite kandi akamaro mu nganda, harimo gusuzuma bagiteri zikora urea, ifumbire ikomoka kuri urea, no kumenya imiti igabanya urea mu kuvura indwara zimwe na zimwe.
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Leupeptin hemisulfate CAS: 103476-89-7
Leupeptin hemisulfate ni umuti ubuza poroteyine ukoreshwa cyane mu bushakashatsi bwa biochemical na biomedical. Ukomoka kuri bagiteri za Streptomyces kandi utuma poroteyine zitandukanye zikora, harimo trypsin, chymotrypsin, na plasmine.
Leupeptin hemisulfate ikunze gukoreshwa mu bushakashatsi bwa laboratwari kugira ngo hirindwe kwangirika kwa poroteyine bidakenewe, kuko poroteyine zishobora kwangiza poroteyine na peptides, bigira ingaruka ku bisubizo by'ubushakashatsi. Mu kubuza imikorere ya poroteyine, leupeptin hemisulfate ifasha mu gutuma poroteyine zituje no kugumana ubuziranenge bwazo mu gihe cy'ubushakashatsi.
Byongeye kandi, leupeptin hemisulfate yakoreshejwe mu bushakashatsi ku miterere y’uturemangingo kugira ngo hamenyekane uruhare rwa poroteyine mu mikorere itandukanye y’uturemangingo, nko gutanga ibimenyetso ku turemangingo, apoptosis, no guhinduranya poroteyine.
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Lipase ikomoka kuri pancreas y'ingurube CAS:9001-62-1
Lipase ni enzyme ihindura lipide mu buryo bwa hydrolysis, cyane cyane isenyuka rya triglycerides rigahinduka aside irike na glycerol. Ikorwa n'ibinyabuzima bitandukanye, birimo inyamaswa, ibimera, na mikorobe. Lipase igira uruhare runini mu igogora, kuko ifasha mu gusenya no kwinjiza ibinure mu mara mato. Byongeye kandi, lipase ifite akamaro kenshi mu nganda nko gutunganya ibiribwa, gukora isuku, imiti, no gukora ibikomoka kuri biofuel. Ubushobozi bwayo bwo gukamura lipide butuma igira akamaro mu mirimo nko guhindura lipide, kongera uburyohe, no gukuramo amavuta.
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Lysostafini CAS:9011-93-2 Igiciro cy'umukozi
Lysostaphine ni enzyme ikomeye irwanya udukoko twibasira cyane cyane Staphylococcus aureus, bagiteri itera indwara zitandukanye mu bantu. Ikomoka kuri bagiteri Staphylococcus simulans kandi ifite ubushobozi bwo gusenya urukuta rw'uturemangingo twa S. aureus, bigatuma isenyuka.
Iyi enzyme yibasira by’umwihariko urwego rwa peptidoglycan rw’urukuta rw’uturemangingo twa bagiteri, ikangiza imiterere yarwo ndetse igatera lysis ya bagiteri. Ubu buryo budasanzwe bwo gukora butuma lysostaphine igira ingaruka nziza ku bwoko bwa S. aureus, harimo n’izidakira imiti ikoreshwa cyane.
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L-Lactate dehydrogenase CAS: 9001-60-9
L-Lactate dehydrogenase (LDH) ni enzyme igira uruhare runini mu mikorere y'ingufu z'uturemangingo, cyane cyane mu guhindura pyruvate muri lactate. Itera imbaraga mu guhindura L-lactate muri pyruvate, ikoresha NAD+ nk'ikintu gihuza.
LDH iboneka mu ngingo zitandukanye z'umubiri, harimo umwijima, umutima, imitsi, n'uturemangingo dutukura tw'amaraso. Ingano y'imikorere yayo ishobora kuba ikimenyetso cyo gusuzuma indwara zimwe na zimwe, nko kwangirika k'umwijima, indwara y'umutima ifata imitsi, na kanseri imwe n'imwe.
Inshingano nyamukuru ya LDH ni ugukomeza kuringaniza ingufu z'uturemangingo binyuze mu koroshya ihinduka rya pyruvate, umusaruro wa glycolysis, muri lactate. Iyi nzira izwi nka anaerobic glycolysis, ibaho iyo ogisijeni idafite kandi igatuma uturemangingo dukomeza gukora ingufu iyo umwuka wa ogisijeni ugabanutse.
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Pepsin CAS: 9001-76-7 Igiciro cy'umukozi
Pepsini ni enzyme yo mu gifu iboneka mu gifu igira uruhare runini mu igogora no gusenya poroteyine. Iri mu itsinda rya enzymes zitwa proteases, zishinzwe gusenya poroteyine mo peptides nto na aside amine, bigatuma zinjira mu mara mato.
Pepsini ikorwa kandi igakurwa n'uturemangingo turi mu gifu, tuzwi nka selile nkuru, mu buryo budakora bwitwa pepsinogen. Iyo ibiryo byinjiye mu gifu, bituma aside yo mu gifu irekurwa, igahindura pepsinogen mu buryo bwayo budakora, pepsine. Pepsini ikora neza mu kirere gifite aside, kuko pH nke y'igifu ifasha gukora no gukomeza imikorere ya enzyme.
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Inyongera ya Poroteyine Kinase KT5823 CAS: 126643-37-6
Inyongera ya poroteyine kinase KT5823 ni ikintu gito kibuza poroteyine kinase kwibasira no kubuza imikorere ya poroteyine kinase. Proteyine kinase ni enzymes zituma poroteyine zikora phosphoryl mu kongeramo amatsinda ya phosphate mu bisigazwa bya aside amine runaka, akenshi serine, threonine, cyangwa tyrosine. Iyi gahunda ya phosphoryl bigira uruhare runini mu nzira zitandukanye zo gutanga ibimenyetso ku ngirabuzimafatizo, kugenzura imikorere ya poroteyine, no kugenzura imikorere y’ingirabuzimafatizo nko gukura kw’ingirabuzimafatizo, kwigabanyamo ibice, gutandukanya ibice, no kuzura kw’ingirabuzimafatizo.
KT5823 ikunze gukoreshwa mu bushakashatsi kugira ngo ikore ubushakashatsi ku mikorere n'inzira z'ibimenyetso bya poroteyine kinase. Mu gukumira poroteyine kinase, KT5823 ishobora gufasha abashakashatsi kumenya poroteyine n'inzira zihariye zigirwaho ingaruka n'imikorere ya kinase. Aya makuru ashobora kuba ingirakamaro mu gusobanukirwa uruhare rwa poroteyine kinase mu mikorere y'uturemangingo no kumenya intego nshya zo kuvura.
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CAS ya Pyridoxal-5′-phosphate monohydrate:41468-25-1
Pyridoxal-5′-phosphate monohydrate, izwi kandi nka PLP, ni ubwoko bwa vitamine B6 ikora. Ni coenzyme y'ingenzi igira uruhare mu bikorwa bitandukanye bya enzyme mu mubiri. PLP igira uruhare runini mu mikorere ya aside amine, imikorere ya neurotransmitter, no gukora heme, igice cya hemoglobin.
PLP ikora nka coenzyme ihuza na enzymes runaka kandi igafasha mu mikorere y’ibinyabutabire. Ikora nk'ingufu, yorohereza guhindura ibintu bitandukanye, nka aside amine, mo ibintu bitandukanye. PLP ni ingenzi cyane mu mikorere ya aside amine, nko guhindura tryptophan muri serotonin, cyangwa gusenya glycine muri serine.
Uretse uruhare rwayo mu mikorere y’aside amine, PLP inagira uruhare mu gukora imisemburo y’uturemangingo nka dopamine, norepinephrine, na aside gamma-aminobutyric (GABA). Izi misemburo ni ingenzi cyane ku mikorere myiza y’ubwonko kandi zikagira uruhare mu kugenzura amarangamutima, kumenya, no kohereza ibimenyetso hagati y’uturemangingo tw’imitsi.
Byongeye kandi, PLP ni ngombwa mu gukora heme, igice cya hemoglobine iboneka mu turemangingo dutukura tw’amaraso. Hemoglobine ishinzwe gutwara ogisijeni mu mubiri wose, bigatuma PLP iba ingenzi mu kubungabunga urugero rusanzwe rwa ogisijeni no gutuma ingingo n’ingingo bitandukanye bikora neza.
Bitewe n'akamaro kayo mu mikorere myinshi ya biochemical, inyunganiramirire ya PLP rimwe na rimwe igirwa inama ku bantu bafite indwara zimwe na zimwe cyangwa ibibura bigira ingaruka ku mikorere ya Vitamine B6. Iboneka mu buryo bw'inyongeramusaruro kandi ishobora kwandikirwa n'abashinzwe ubuvuzi bitewe n'ibyo bakeneye byihariye.
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Reductase, glutathione CAS:9001-48-3
Glutathione reductase ni enzyme igira uruhare runini mu kubungabunga uburinganire bwa glutathione yagabanutse kandi ikaranze (GSH / GSSG) mu turemangingo. Glutathione ni tripeptide igizwe na aside amine glycine, cysteine, na glutamate. Ikora nk'ikintu gikomeye kirwanya uturemangingo kandi igira uruhare mu mikorere itandukanye y'uturemangingo, harimo gukurura no gusana ADN, no gukora poroteyine.
Glutathione reductase igabanya glutathione (GSSG) kugeza ku rugero rwayo rugabanutse (GSH) ikoresheje NADPH (nicotinamide adenine dinucleotide phosphate) nk'ikintu gifasha mu gutuma glutathione igabanuka mu turemangingo, kuko GSSG ishobora kwirundanya iyo hari ikibazo cy'imisemburo ya oxidative.
Mu gukomeza igipimo gikwiye cya GSH na GSSG, glutathione reductase ifasha kurinda uturemangingo kwangirika kwa ogisijeni guterwa n’ubwoko bwa ogisijeni (ROS) n’izindi molekile zangiza. Ikora nk'ingenzi mu kurinda uturemangingo twa ogisijeni.
Byongeye kandi, glutathione reductase inagira uruhare mu kongera gukoresha glutathione disulfide (GSSG) ikorwa mu gihe cy'imikorere itandukanye ya metabolic, bigatuma habaho kugabanuka kwa glutathione (GSH) mu mikorere yayo myinshi y'uturemangingo.
