Inyongera ya Poroteyine Kinase KT5823 CAS: 126643-37-6

Inyongera ya poroteyine kinase KT5823 ni ikintu gito kibuza poroteyine kinase kwibasira no kubuza imikorere ya poroteyine kinase. Proteyine kinase ni enzymes zituma poroteyine zikora phosphoryl mu kongeramo amatsinda ya phosphate mu bisigazwa bya aside amine runaka, akenshi serine, threonine, cyangwa tyrosine. Iyi gahunda ya phosphoryl bigira uruhare runini mu nzira zitandukanye zo gutanga ibimenyetso ku ngirabuzimafatizo, kugenzura imikorere ya poroteyine, no kugenzura imikorere y’ingirabuzimafatizo nko gukura kw’ingirabuzimafatizo, kwigabanyamo ibice, gutandukanya ibice, no kuzura kw’ingirabuzimafatizo.

KT5823 ikunze gukoreshwa mu bushakashatsi kugira ngo ikore ubushakashatsi ku mikorere n'inzira z'ibimenyetso bya poroteyine kinase. Mu gukumira poroteyine kinase, KT5823 ishobora gufasha abashakashatsi kumenya poroteyine n'inzira zihariye zigirwaho ingaruka n'imikorere ya kinase. Aya makuru ashobora kuba ingirakamaro mu gusobanukirwa uruhare rwa poroteyine kinase mu mikorere y'uturemangingo no kumenya intego nshya zo kuvura.

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Ishyirwa mu bikorwa n'ingaruka

Inyongera ya poroteyine kinase KT5823 ni umuti ukoreshwa cyane mu gukumira poroteyine kinase G (PKG), cyane cyane wibasira ubwoko bwa I isoform PKG-1. PKG ni serine/threonine kinase igira uruhare runini mu mikorere itandukanye y’uturemangingo nko kuruhuka imitsi neza, guteranya platelets, no kugenzura uburyo vasodilation ikorwa.

Ingaruka nyamukuru za KT5823 ni ukubuza ibikorwa bya PKG-1 mu guhangana na ATP ifatanya na kinase domaine. Mu kubuza PKG-1, KT5823 ishobora kubangamira inzira zo gutanga ibimenyetso ziri munsi ya PKG-1, harimo n'ibyiciro by'ibimenyetso bishingiye kuri cGMP.

Ikoreshwa rya KT5823 ahanini riri mu bushakashatsi kugira ngo hamenyekane imikorere n'inzira z'ibimenyetso bya PKG-1. Ikoreshwa ryayo mu kubuza imikorere ya PKG-1 rituma abashakashatsi basesengura uruhare rwa PKG-1 mu mikorere itandukanye y'umubiri n'indwara. Harimo zimwe mu ngamba zihariye za KT5823:

Gukora iperereza ku kuruhuka kw'imitsi: PKG-1 igira uruhare runini mu kuruhuka kw'imitsi. Mu gukumira PKG-1 hakoreshejwe KT5823, abashakashatsi bashobora kwiga uburyo n'inzira bifashisha mu kuruhuka kw'imitsi, ibyo bikaba ari ingenzi mu nzego nk'ubushakashatsi ku mitsi n'umutima.

Kwiga uburyo platelet yibumbira: PKG-1 inagenga uburyo platelet yibumbira hamwe n’imiterere y’amaraso. Kubuza PKG-1 na KT5823 bituma abashakashatsi basuzuma ingaruka z’ibikorwa bya PKG-1 ku mikorere ya platelet no gusobanukirwa inzira zibitera.

Gusuzuma intego za PKG-1: Mu gukumira PKG-1, abashakashatsi bashobora kumenya no kwiga intego za PKG-1 n'ingaruka za PKG-1, bagatanga ubumenyi ku mikorere ya molekile ishingiye ku gusubiza kwa selile kwa PKG-1.

Gupakira ibicuruzwa:

Amakuru y'inyongera:

Imiterere	C29H25N3O5
Isuzuma	99%
Isura	Ifu y'umweru
Nimero ya CAS	126643-37-6
Gupakira	Bito kandi byinshi
Igihe cyo Kubika	Imyaka 2
Ububiko	Bika ahantu hakonje kandi humutse
Icyemezo	ISO.