CAS ya Pyridoxal-5′-phosphate monohydrate:41468-25-1

Pyridoxal-5′-phosphate monohydrate, izwi kandi nka PLP, ni ubwoko bwa vitamine B6 ikora. Ni coenzyme y'ingenzi igira uruhare mu bikorwa bitandukanye bya enzyme mu mubiri. PLP igira uruhare runini mu mikorere ya aside amine, imikorere ya neurotransmitter, no gukora heme, igice cya hemoglobin.

PLP ikora nka coenzyme ihuza na enzymes runaka kandi igafasha mu mikorere y’ibinyabutabire. Ikora nk'ingufu, yorohereza guhindura ibintu bitandukanye, nka aside amine, mo ibintu bitandukanye. PLP ni ingenzi cyane mu mikorere ya aside amine, nko guhindura tryptophan muri serotonin, cyangwa gusenya glycine muri serine.

Uretse uruhare rwayo mu mikorere y’aside amine, PLP inagira uruhare mu gukora imisemburo y’uturemangingo nka dopamine, norepinephrine, na aside gamma-aminobutyric (GABA). Izi misemburo ni ingenzi cyane ku mikorere myiza y’ubwonko kandi zikagira uruhare mu kugenzura amarangamutima, kumenya, no kohereza ibimenyetso hagati y’uturemangingo tw’imitsi.

Byongeye kandi, PLP ni ngombwa mu gukora heme, igice cya hemoglobine iboneka mu turemangingo dutukura tw’amaraso. Hemoglobine ishinzwe gutwara ogisijeni mu mubiri wose, bigatuma PLP iba ​​ingenzi mu kubungabunga urugero rusanzwe rwa ogisijeni no gutuma ingingo n’ingingo bitandukanye bikora neza.

Bitewe n'akamaro kayo mu mikorere myinshi ya biochemical, inyunganiramirire ya PLP rimwe na rimwe igirwa inama ku bantu bafite indwara zimwe na zimwe cyangwa ibibura bigira ingaruka ku mikorere ya Vitamine B6. Iboneka mu buryo bw'inyongeramusaruro kandi ishobora kwandikirwa n'abashinzwe ubuvuzi bitewe n'ibyo bakeneye byihariye.