L-Lactate dehydrogenase CAS: 9001-60-9

Ingaruka za L-Lactate dehydrogenase (LDH) zirimo uruhare rwayo mu mikorere y'ingufu z'uturemangingo ndetse no kugira uruhare mu guhindura pyruvate muri lactate. LDH ifasha kubungabunga ingufu mu turemangingo binyuze mu koroshya ihinduka rya pyruvate, umusaruro w'ingufu z'isukari, muri lactate. Iyi nzira, izwi nka anaerobic glycolysis, ibaho iyo umwuka wa ogisijeni ugabanutse.

LDH kandi igira uruhare runini mu kongera gukoresha lactate. Mu gihe cy'imyitozo ngororamubiri ikomeye cyangwa iyo umwuka wa ogisijeni uboneka hasi, lactate ishobora kwirundanya mu ngingo. LDH ifasha kongera gukoresha lactate mu kuyihindura pyruvate, hanyuma igakoreshwa nk'ishingiro ryo gukora ingufu cyangwa igahinduka glucose binyuze muri gluconeogenesis. Ubu buryo bwo kongera gukoresha lactate butuma uturemangingo dushobora gukoresha lactate neza nk'isoko y'ingufu kandi bigafasha gukumira kwiyongera kwa lactate, bishobora kwangiza imikorere y'uturemangingo.

LDH ifite akamaro kenshi mu buvuzi. Imwe mu mikoreshereze yayo ikomeye ni nk'ikimenyetso cyo gusuzuma indwara zimwe na zimwe. Ingano nyinshi ya LDH mu maraso ishobora kugaragaza ko ingingo zangiritse cyangwa ko hari indwara nko kwangirika k'umwijima, indwara y'umutima, ndetse n'ubwoko bumwe na bumwe bwa kanseri. Ingano ya LDH ikunze gukurikiranwa mu buvuzi kugira ngo harebwe uko indwara igenda itera n'uko ivurwa.