Leflunomide CAS: 75706-12-6 Utanga ibicuruzwa

Leflunomide idakora, ariko teriflunomide ibuza synthesis ya pyrimidine de novo kumiti mike yo kuvura ihagarika dihydroorotate dehydrogenase (enzyme igena igipimo cya synthesis ya UMP), igabanya ADN na RNA ikomatanya, hamwe no gufata ingirabuzimafatizo zikwirakwizwa no gukora antibodies.Kugabanuka kwa dihydroorotate kuri orotate bibaho hamwe no kugabanya cofactor yayo, ubiquinone (coenzyme Q).Kubuza dihydroorotate dehydrogenase na teriflunomide yerekana kinetics idahiganwa kandi idahiganwa.Ubuyobozi bwa leflunomide ku barwayi barwaye rubagimpande ya rubagimpande itera kuvanaho buhoro buhoro selile B no kugabanya imikorere yubudahangarwa.