Letrozole CAS: 112809-51-5 Umukozi Ukora

Letrazole ishobora gukorwa mu ntambwe ebyiri uhereye kuri 4- bromomethyl-benzonitrile hamwe na 1,2,4-triazole kandi ni inhibitor ya aromatase yo mu gisekuru cya gatatu. Ni inhibitor yihariye ya P450arom ibuza ihinduka rya androstenedione muri estrone. Kugabanuka kwa estrogen yo mu maraso byahise kandi bimara igihe kirekire. Ibi bigerwaho nta gukumira izindi steroid biosynthesis bituma iba inhibitor ya aromatase itoranywa cyane yapimwe. Letrazole ifite imikorere itangaje yo kurwanya ikibyimba, yihanganirwa neza kandi nta ngaruka mbi ifite. Ifite imbaraga zikubye inshuro 10.000 kurusha aminoglutethimide, mu mubiri, inhibitor ya mbere ya aromatase yamenyekanye neza.