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N-Acetyl-L-cysteine CAS: 616-91-1
N-Acetyl-L-cysteine (NAC) ni ubwoko bwa aside amine cysteine yahinduwe. Itanga isoko ya cysteine kandi ishobora guhinduka tripeptide glutathione, antioxidant ikomeye mu mubiri. NAC izwiho ubushobozi bwayo bwo kurwanya antioxidant na mucolytic, bigatuma igira akamaro mu bikorwa bitandukanye by'ubuzima.
Nk’umuti urwanya imisemburo, NAC ifasha mu kurinda uturemangingo kwangirika guterwa na radicals libre, ubwoko bwa ogisijeni ikora, n’uburozi. Ifasha kandi mu gukora glutathione, igira uruhare runini mu bikorwa byo gusohora uburozi mu mubiri no kubungabunga ubudahangarwa bw’umubiri.
NAC yakorewe ubushakashatsi ku nyungu zayo mu buzima bw'ubuhumekero, cyane cyane ku bantu bafite indwara nka bronchitis idakira, COPD, na cystic fibrosis. Ikunze gukoreshwa nk'umuti wo gusohora imyanda mu gufasha kugabanya no koroshya imiyoboro y'ubuhumekero, bigatuma byoroha gusukura inzira z'ubuhumekero.
Byongeye kandi, NAC yagaragaje icyizere mu gushyigikira ubuzima bw'umwijima ifasha mu gukuraho ibintu by'uburozi, nka acetaminophen, umuti usanzwe ugabanya ububabare. Ishobora kandi kugira ingaruka zo kurinda umwijima kwangirika guterwa no kunywa inzoga.
Uretse kuba ifite ubushobozi bwo kurwanya indwara ziterwa n’ubudahangarwa bw’umubiri (antioxidant) n’ubufasha mu guhumeka, NAC yanasuzumwe ku nyungu zayo mu buzima bwo mu mutwe. Ubushakashatsi bumwe bwerekana ko ishobora kugira ingaruka nziza ku ndwara zo mu mutwe, nko kwiheba no kudakora ibintu bikunze kugorama (OCD).
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GLYCYL-L-PROLINE CAS: 704-15-4
Glycyl-L-proline, izwi kandi nka glycylproline cyangwa Gym-Pro, ni aside amine ikomoka kuri aside amine glycine ifatanye na aside amine L-proline. Ni ikintu gisanzwe kiboneka muri kolajeni, poroteyine ishinzwe imiterere n'imbaraga by'ingingo zitandukanye mu mubiri. Glycyl-L-proline yakozweho ubushakashatsi ku nyungu zayo ku buzima, harimo guteza imbere ubuzima bw'uruhu, kugabanya ububyimbirwe, no gushyigikira ubuzima bw'ingingo n'amagufwa. Ikoreshwa kandi mu buryo bwo kwisiga kubera ubushobozi bwayo bwo koroshya no kurwanya antioxydants.
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Guanidine Hydrochloride CAS: 50-01-1
Guanidine hydrochloride ni ikinyabutabire gifite formula ya molekile CH5N3·HCl. Ni ikintu gikomeye cya chaotropic gikoreshwa cyane mu bushakashatsi bwa biochimie na molekile.
Guanidine hydrochloride ikunze gukoreshwa mu gushonga poroteyine, kwangiza imiterere ya poroteyine, no gukwirakwiza poroteyine mu rwego rwo kuyisukura. Igira akamaro cyane mu gusenya imigozi ya hydrogen no kubangamira imikoranire idahuza poroteyine. Iyi miterere ituma igira akamaro mu gushonga poroteyine zisanzwe zidashonga cyangwa zikunze guhurira hamwe.
Ikoreshwa kandi nk'ikintu gikomeza poroteyine, ikarinda poroteyine kwivanga cyangwa kwangirika bidakenewe mu gihe cy'igerageza ritandukanye rya biochemical na biophysical. Guanidine hydrochloride ishobora gufasha kubungabunga imiterere n'imikorere ya poroteyine mu gihe cyo kwangirika..
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Asetilikolini iyode CAS:1866-15-5
Acetylthiocholine iyoodide ni ikinyabutabire gikunze gukoreshwa nk'igice cy'ingenzi mu isuzuma rya enzyme kugira ngo hamenyekane imikorere ya enzyme acetylcholinesterase (AChE). AChE ni enzyme ikoresha hydrolyze ya acetylcholine mu mitsi, intambwe y'ingenzi mu guhagarika ihererekanya ry'ibimenyetso hagati y'uturemangingo tw'imitsi.
Iyo iyode ya acetylthiocholine ikoreshejwe na AChE, itsinda rya acetyl rirakurwaho, bigatuma habaho iyoni za thiocholine na acetate. Thiocholine ihita ikora ikoresheje reagent idafite ibara yitwa DTNB (5,5′-dithiobis (aside 2-nitrobenzoic)) kugira ngo ikore imvange y'umuhondo yitwa 5-thio-2-nitrobenzoate, ishobora gupimwa hifashishijwe spectrophotometric. Igipimo cy'iterambere ry'amabara gihuye neza n'imikorere ya AChE mu gipimo.
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2-Methoxy-4-morpholinobenzenediazonium chloride zinc chloride umunyu uvanze (21) CAS: 67801-08-5
2-Methoxy-4-morpholinobenzenediazonium chloride zinc chloride umunyu w’ibice bibiri ni ikintu gikomeye cya kristale gikoreshwa nk’ikintu gihindura imiterere y’ibinyabuzima. Kigizwe na diazonium cation, anions za chloride, na zinc cations. Iki kintu gitanga ubushobozi bwo guhagarara no gushonga, bigatuma kiba cyiza mu bintu bitandukanye bya shimi n’imiti.
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4,5-Diazafluoren-9-one CAS:50890-67-0
4,5-Diazafluoren-9-one ni ikinyabutabire kiri mu bwoko bw'ibinyabutabire bitagira uruhu. Kigizwe n'agatsiko ka fluorene gafite atome ebyiri za azote (diaza) na atome ya ogisijeni (imwe) ifatanye ahantu runaka. Ikunze gukoreshwa nk'inkingi y'ubwubatsi cyangwa igice cyo hagati mu gukora organic synthesis, cyane cyane mu gutegura organic compounds zitandukanye, imiti, n'irangi. Imiterere yayo n'uburyo ikora bituma iba igikoresho cy'agaciro mu gukora imiterere itandukanye ya molekile n'amatsinda y'imikorere.
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Tapso Sodium CAS: 105140-25-8 Igiciro cy'umukozi
aside 3-[N-Tris(hydroxymethyl)methylamino]-2-hydroxypropanesulfonic,Ni njyesa zwitterionic buffering agent mu buryo bw'umunyu wa sodium. Ikunze gukoreshwa mu bushakashatsi bwa biochemical na molekile kugira ngo pH ikomeze kuba ihamye mu bisubizo.It Irashongesha cyane mu mazi kandi ifite pKa hafi ya pH y’umubiri, bigatuma ikoreshwa mu buryo butandukanye nko gutunganya poroteyine, gusuzuma enzymes, gusesengura uturemangingo, no gukoresha electrophoresis. Imiterere yayo yihariye ya shimi n’uburyo ihura na biology bituma iba ingenzi mu mabwiriza atandukanye ya laboratwari.
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4-Nitrophenyl phosphate di(tris) umunyu CAS:68189-42-4
Umunyu wa 4-Nitrophenyl phosphate di(tris) ni ikinyabutabire gikoreshwa mu bushakashatsi no gusuzuma ibinyabutabire. Ukunze gukoreshwa nk'ishingiro ry'ibizamini bya alkaline phosphatase. Uyu munyu, iyo ukozwe hidrolised na alkaline phosphatase, ukora ikintu gifite ibara ry'umuhondo gishobora gupimwa byoroshye hifashishijwe spectrophotometric. Iki gikorwa gikoreshwa cyane mu bikorwa bitandukanye, harimo ibizamini bya enzyme-linked immunosorbent assays (ELISAs) no kumenya ibikorwa bya phosphatase. Ubukana bw'ibara ry'umuhondo bungana neza n'ibikorwa bya enzyme, bigatuma haboneka neza urugero rwa alkaline phosphatase mu bipimo by'ibinyabuzima. Umunyu wa 4-Nitrophenyl phosphate di(tris) urahamye, ushonga mu mazi, kandi urushaho kugira ingaruka nziza, bigatuma uba amahitamo akunzwe yo gupima enzymes mu bushakashatsi bw'ibinyabuzima n'ubw'ubuvuzi.
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Nitrotetrazolium blue chloride CAS:298-83-9
Nitrotetrazolium blue chloride, izwi kandi nka NBT cyangwa NBT-Cl, ni ikinyabutabire gikunze gukoreshwa mu isuzuma ry’ibinyabuzima n’ibinyabutabire. Ni ifu y’umuhondo werurutse ishongeshwa mu mazi.
NBT ikunze gukoreshwa nk'ikimenyetso cyo kumenya niba hari superoxide radicals cyangwa enzymes zibikora. Ihinduka ibara iyo igabanutse na superoxide radicals, ikava ku muhondo ikajya ku bururu bwijimye bwa formazan. Iyi reaction ikunze gukoreshwa mu bushakashatsi bwo kwiga stress ya oxidative, guhumeka kw'uturemangingo, n'imikorere ya enzymes.
NBT ikunze gukoreshwa mu buryo butandukanye, nko kugabanya nitroblue tetrazolium, kugira ngo igaragaze ikorwa rya superoxide mu turemangingo no mu ngingo. Yanakoreshejwe muri immunohistochemistry na histochemistry kugira ngo hamenyekane kandi hamenyekane izindi enzymes n'ibice bigize uturemangingo.
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NSP-AS CAS:211106-69-3 Igiciro cy'umukozi
Umunyu w'imbere wa 3-[9-((3-(carboxypropyl)[4-Methxylphenyl]sulfonyl)aMine)carboxyl]-10-acridiniuMyl)-1-propanesulfonate ni molekile igizwe n'igice cya acridinium gifatanye n'umunyu w'imbere wa propanesulfonate. Irimo itsinda rya carboxypropyl, itsinda rya 4-Methxylphenylsulfonyl, n'itsinda rya amine. Iki gice gishobora kuba cyarakorewe gukoreshwa mu buryo bwihariye nko mu butabire, mu by'imiti, cyangwa mu bushakashatsi.
Byongeye kandi, NAC yagaragaje icyizere mu gushyigikira ubuzima bw'umwijima ifasha mu gukuraho ibintu by'uburozi, nka acetaminophen, umuti usanzwe ugabanya ububabare. Ishobora kandi kugira ingaruka zo kurinda umwijima kwangirika guterwa no kunywa inzoga.
Uretse kuba ifite ubushobozi bwo kurwanya indwara ziterwa n’ubudahangarwa bw’umubiri (antioxidant) n’ubufasha mu guhumeka, NAC yanasuzumwe ku nyungu zayo mu buzima bwo mu mutwe. Ubushakashatsi bumwe bwerekana ko ishobora kugira ingaruka nziza ku ndwara zo mu mutwe, nko kwiheba no kudakora ibintu bikunze kugorama (OCD).
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L-Leucine p-nitroanilide hydrochloride CAS: 16010-98-3
L-Leucine p-nitroanilide hydrochloride ni ikinyabutabire kiri mu itsinda ry’ibikomoka kuri p-nitroanilide. Ni ifu y’umweru kugeza ku umweru ikoreshwa cyane mu bushakashatsi bwa biochemical no mu isuzuma rya enzymes.
L-Leucine p-nitroanilide hydrochloride ikunze gukoreshwa nk'igice cyo gupima imikorere ya enzymes nka poroteyine na peptidase. Iyo izi enzymes zivanzemo L-Leucine p-nitroanilide hydrochloride, isohora p-nitroaniline, ishobora kugaragara hifashishijwe spectrophotometric. Igipimo cy'impinduka z'amabara gihuye neza n'imikorere ya enzymes, bigatuma umubare w'imikorere ya enzymes mu bipimo by'ibinyabuzima upimwa.
Iki kintu kirashongeshwa mu mazi kandi gishobora gushongeshwa byoroshye mu bisubizo bikwiye byo gukoreshwa mu gusuzuma enzymes. Ni ngombwa kubika L-Leucine p-nitroanilide hydrochloride ahantu hakonje kandi humutse kugira ngo gikomeze kuba cyiza.
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Guanidine Thiocyanate Sulfate CAS: 593-84-0
Sulfate ya Guanidine thiocyanate ni imvange y’ibinyabutabire ikomoka kuri iyoni za guanidine, thiocyanate, na sulfate. Ikunze gukoreshwa mu bushakashatsi bwa biology ya molekile na biochimie nk'ikintu gitera chaotropic.
Guanidine thiocyanate sulfate ikunze gukoreshwa muri gahunda zo gutandukanya ADN na RNA kugira ngo ihagarike uturemangingo tw’uturemangingo na poroteyine zidafite ubuziranenge, bigatuma aside nucleic zikurwamo neza. Ifasha mu gushonga kwa ADN na RNA, bigatuma bikurwamo kandi bigatunganywa mu buryo butandukanye.
Bitewe n’imiterere yayo ya chaotropic, guanidine thiocyanate sulfate ifasha mu gusenya hydrogen bond n’ibindi bikorwa bitari covalent, yorohereza gutandukanya aside nucleic na poroteyine, lipide, n’ibindi bice by’uturemangingo. Ifasha kandi mu kubuza imikorere ya RNase, ikerekana ubuziranenge n’ubuziranenge bwa aside nucleic zakuwemo..
