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Cytidine-5′-monophosphate (CMP), aside yigenga CAS:63-37-6
Cytidine 5'-monophosphate (CMP) ni nucleotide ikora nk'inkingi y'ubwubatsi bwo gukora no guhindura RNA. Ni igice cy'ingenzi mu kubaka molekile za RNA kandi igira uruhare mu bikorwa nko gufunga mRNA no gutunganya nucleus. CMP ikoreshwa kandi mu bushakashatsi bwa biochemical na molekile mu bijyanye n'ikoreshwa nko kwandika muri vitro no gushyira ibirango bya aside nucleic. Uruhare rwayo mu gutunganya RNA no kuyikoresha mu buryo butandukanye bwo kugerageza bituma iba igikoresho cy'ingenzi mu gusobanukirwa imiterere n'imikorere ya molekile za RNA.
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IBMX, 3-isobutyl-1-methylxanthine CAS:28822-58-4
3-isobutyl-1-methylxanthine, izwi kandi nka IBMX, ni methylxanthine ikomoka kuri methylxanthine ikunze gukoreshwa mu bushakashatsi bwa siyansi nk'umuti utari uwa kamere wa cyclic nucleotide phosphodiesterases. Bizwiho kongera urugero rwa cyclic AMP (cAMP) na cyclic GMP (cGMP) mu ngirabuzimafatizo mu gukumira kwangirika kwazo, ibyo bikaba bishobora guhindura inzira zitandukanye zo gutanga amakuru ku ngirabuzimafatizo.
Uretse ubushakashatsi bwayo, IBMX yakoreshejwe mu buvuzi bumwe na bumwe kubera ingaruka zayo zo kwangiza imitsi no kwangiza imitsi. Ariko, ikoreshwa ryayo mu buvuzi bw'abantu ni nkeya.
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4-Nitrophenyl phosphate disodium salt hexahydrate CAS: 4264-83-9
4-Nitrophenylphosphate disodium salt hexahydrate ni ikinyabutabire gikunze gukoreshwa mu bushakashatsi bwa biochemical na farumasi. Ni umunyu wa 4-nitrophenylphosphate, urimo iyoni ebyiri za sodium na molekile esheshatu z'amazi. Iki kinyabutabire gikunze gukoreshwa nk'ishingiro ry'ibizamini bya phosphatase no mu inyigo ya kinetics ya enzyme.
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5′-Deoxy-5-fluorocytidine CAS: 66335-38-4
5′-Deoxy-5-fluorocytidine ni ubwoko bwa nucleoside analog y’ubukorano burimo gukorwaho ubushakashatsi ku mikorere yayo yo kurwanya virusi, cyane cyane ku barwayi ba RNA nka virusi ya hepatite C (HCV) na flavivirusi. Ikora mu kubangamira ukwiyongera kw'uturemangingo tw’uturemangingo twa virusi, amaherezo ikabuza virusi ubushobozi bwo kugwira no gukwirakwira mu mubiri.
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Cytidine-5′-triphosphate (CTP), umunyu wa disodium CAS: 652154-13-7
Cytidine-5′-triphosphate (CTP), umunyu wa disodium ni triphosphate ya nucleoside ikora nk'inkingi y'ubwubatsi bwo gukora RNA. Igira uruhare runini mu gukora imikorere y'uturemangingo kandi ni ingenzi mu kohereza amakuru ya genetiki kuva kuri ADN kugera kuri RNA mu gihe cyo kwandika. CTP ikoreshwa cyane mu bushakashatsi ku binyabuzima bya molekile, cyane cyane mu bushakashatsi bujyanye no gukora RNA, kwivanga kwa RNA, n'izindi nzira zijyanye na RNA. Byongeye kandi, ikoreshwa mu bikorwa bya enzyme, inyigo ku gukora imikorere ya nucleotide, ndetse no nk'ishingiro ry'ibizamini bitandukanye bya biochemical. Mu nganda zikora imiti, CTP ishobora kandi gukoreshwa mu guteza imbere imiti irwanya virusi na kanseri.
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ITP, inosine 5′-triphosphate trisodium umunyu CAS: 35908-31-7
Umunyu wa Inosine-5′-triphosphate trisodium, ukunze kuvugwa mu magambo make nka ITP-Na3, ni ubwoko bwa inosine ya triphosphate, ni ukuvuga nucleoside igira uruhare runini mu mikorere itandukanye ya biyoloji. Iki kinyabutabire ni umunyu, bigatuma gishonga mu mazi kandi kikaba gikwiriye gukoreshwa mu isuzuma rya biochemical na enzymatic, ndetse no mu bushakashatsi ku binyabuzima bya molekile. Umunyu wa Inosine-5′-triphosphate trisodium ukoreshwa mu kwiga uburyo enzymatic ikora, interconversion ya nucleotide, ndetse no nk'umusemburo w'imisemburo imwe n'imwe. Ikoreshwa ryayo rinagera no ku nyigo za analog za nucleotide ndetse no mu gutegura uruvange rwa nucleotide rukoreshwa mu buhanga bwa molekile.
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5-Bromouracil CAS: 51-20-7 Igiciro cy'umukozi
5-Bromouracil ni ubwoko bwa synthetic analogue ya uracil, ikaba ari igice cya RNA. 5-Bromouracil ishobora gushyirwa muri aside nucleic kandi ishobora gutera impinduka mu miterere y’ibinyabuzima bitewe no kwangirika nabi kwa guanine mu gihe cyo kwibasira ADN. Ikoreshwa nk'umuti mu bushakashatsi bwa genetiki mu kwiga igipimo cy’impinduka mu miterere n’uburyo zikorwamo.
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5-Fluoro-2′-deoxyuridine CAS:50-91-9
5-Fluoro-2′-deoxyuridine ni analoge y’ibinyabutabire bya nyukleoside ibuza imikorere ya ADN. Yakoreweho ubushakashatsi ku miterere yayo ishobora kurwanya indwara ziterwa na virusi n’ibibyimba. Byongeye kandi, ikoreshwa nk'igikoresho cy'ubushakashatsi mu binyabuzima bya molekile na biochimie.
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Umunyu wa disodium wa Cytidine-5′-triphosphate CAS:36051-68-0
Umunyu wa disodium wa Cytidine-5′-triphosphate (CTP-Na2) ni triphosphate ya nucleoside ikora nk'inkingi y'ubwubatsi mu gukora RNA. Igira uruhare runini mu mikorere y'uturemangingo, ikora nk'ishingiro rya polymerase za RNA mu kwandika no nk'isoko y'ingufu mu bikorwa bitandukanye bya enzyme. CTP-Na2 ikunze gukoreshwa mu bushakashatsi bwa biochemical na molekile nk'igice mu bikorwa birimo gukora RNA, guhindura no kuyitunganya. Imiterere yayo y'umunyu wa disodium yongera ubushobozi bwayo bwo gushonga mu bisubizo by'amazi, bigatuma yoroha kuyikoresha muri laboratwari.
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Aside ya Ribonucleique ikomoka ku musemburo wa Baker CAS: 63231-63-0
Aside ya Ribonucleic (RNA) ikomoka ku musemburo wa Baker, izwi kandi ku izina rya Saccharomyces cerevisiae, yerekeza ku ngirabuzimafatizo za RNA ziba muri iki gihumyo gisanzwe gifite akaremangingo kamwe. Ikora imirimo itandukanye y'ingenzi mu ngirabuzimafatizo, harimo gukora poroteyine, imikorere ya enzyme, no kugenzura ingirabuzimafatizo. RNA ikomoka ku musemburo wa Baker ishishikaje abahanga mu bya siyansi n'abashakashatsi biga ibijyanye n'ibinyabuzima bya molekile, imiterere y'uturemangingo, n'imikorere y'uturemangingo. Ikoreshwa mu bushakashatsi bwinshi n'ubushakashatsi kugira ngo haboneke ubumenyi ku mikorere ya ngirabuzimafatizo, gutunganya RNA, n'imikorere ya molekile ishingiye ku mikorere y'uturemangingo.
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6-Chloropurine CAS: 87-42-3 Igiciro cy'umukozi
6-Chloropurine ni ikinyabutabire kiri mu muryango wa purine. Ni ikinyabutabire kiva muri purine, ikaba ari ingenzi mu kubaka ADN na RNA. 6-Chloropurine ikoreshwa mu gukora organic synthesis no mu bushakashatsi ku miti nk'intangiriro yo gutegura ibintu bitandukanye biva muri purine n'ibindi binyabutabire mu miti.
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Umunyu wa Adenosine 5′-monophosphate disodium CAS:4578-31-8
Umunyu wa Adenosine 5′-monophosphate disodium, uzwi kandi nka 5′-AMP, ni nucleotide igizwe na adenine, ribose, n'itsinda rya fosifate. Ikora nk'intangiriro ya adenosine triphosphate (ATP), ikaba ari molekile y'ingenzi igira uruhare mu ihererekanya ry'ingufu z'uturemangingo. Mu bushakashatsi no mu mikoreshereze ya biochemical, 5′-AMP ikoreshwa nk'ishingiro mu mikorere ya enzymes, cyane cyane mu bushakashatsi ku mikorere ya nucleotide, inzira zo gutanga ibimenyetso, no nk'igice mu bipimo bitandukanye. Imiterere y'umunyu wayo wa disodium yongera ubushobozi bwo gushonga no guhagarara kwayo, bigatuma ikoreshwa mu igerageza.
