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guanosine 5′- (disodium dihydrogen triphosphate) CAS: 56001-37-7
Guanosine-5′-triphosphate disodium ni imvange ikoreshwa mu buryo butandukanye bwa biochemical, nko mu gukora RNA na ADN, ndetse no mu nzira zo gutanga ibimenyetso. Ni triphosphate ya nucleoside, bivuze ko igizwe na guanosine ya nucleoside ifitanye isano n'amatsinda atatu ya fosifate. Ubwoko bw'umunyu wa disodium bwerekana gusa ko ari umunyu urimo iyoni ebyiri za sodium.
Iyi mvange ni ingenzi mu guhererekanya ingufu z'uturemangingo kandi igira uruhare mu bikorwa bitandukanye bya enzyme. Ni kandi isoko y'ingufu zo gukora poroteyine n'izindi gahunda z'uturemangingo.
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2′-Deoxyuridine CAS:951-78-0 Igiciro cy'umukozi
2′-Deoxyuridine ni nucleoside igizwe na nucleobase uracil ifitanye isano n'isukari ya deoxyribose. Ni ingenzi mu kubaka ADN kandi igira uruhare mu ikorwa ry'ibintu bigize ADN. 2′-Deoxyuridine ikoreshwa mu bushakashatsi bwa siyansi nk'intangiriro yo gukora ADN no mu buryo butandukanye bwa biology. Igira uruhare runini mu gusobanukirwa inzira z'uturemangingo, ndetse no mu iterambere ry'uburyo bushobora gukoreshwa mu kuvura indwara ziterwa na virusi no kuvura kanseri.
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Adenosine5′- (trihydrogen diphosphate), umunyu wa monopotassium, dihydrate (9CI) CAS: 72696-48-1
adenosine 5′- (trihydrogen diphosphate) umunyu wa monopotassium, dihydrate, ni ikinyabutabire kigizwe na adenosine hamwe n'itsinda rya trihydrogen diphosphate n'umunyu wa monopotassium mu buryo bwa dihydrate. Iki kinyabutabire gikunze kwitwa adenosine diphosphate (ADP), gikora uruhare runini mu mikorere itandukanye ya biyoloji, cyane cyane mu kohereza ingufu mu turemangingo.
ADP ni igice cy'ingenzi mu ikoreshwa ry'ingufu mu turemangingo, kuko igira uruhare mu kohereza ingufu mu gihe cyo guhumeka no gukora fotosinthesisi. Ni na yo ibanziriza adenosine triphosphate (ATP), ari nayo itwara ingufu mu turemangingo.
Byongeye kandi, ADP igira uruhare mu nzira zo kohereza ibimenyetso kandi ikaba ari igice cy’ingenzi mu bikorwa bya enzyme. Mu rwego rwa biochimie na molekile, ADP ikoreshwa cyane mu bushakashatsi bujyanye na metabolisme y’uturemangingo, kinetics ya enzyme, n’inzira zo kohereza ingufu.
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Hypoxanthine CAS: 68-94-0 Igiciro cy'umukozi
Hypoxanthine ni ikintu gisanzwe kibaho kandi kikaba ari ingenzi mu kwangirika kwa purine. Ni igice cy'ingenzi cya aside nucleic kandi kigira uruhare mu mikorere itandukanye ya biyoloji, harimo no gukora no gutunganya ADN na RNA. Byongeye kandi, byagaragaye ko hypoxanthine igira uruhare mu ndwara zimwe na zimwe, nka goutte na Lesch-Nyhan syndrome.
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2′-O-Methyluridine CAS: 2140-76-3 Igiciro cy'umukozi
2′-O-Methyluridine ni nucleoside yahinduwe irimo itsinda rya methyl riri ku mwanya wa 2′ w'impeta ya ribose. Ni ingenzi mu gukora molekile za RNA zahinduwe kandi byizweho ku miterere yazo ishobora kubaho mu binyabuzima no mu buvuzi. Zimwe mu mikoreshereze yayo zirimo ikoreshwa mu bushakashatsi bwa RNA, nk'igice mu gukora RNA yahinduwe mu bikorwa byo kuvura no gukora genome, ndetse n'igikoresho mu kwiga imiterere n'imikorere ya RNA.
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4-Amino-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one CAS:951-77-9
2′-Deoxycytidine ni nucleoside igizwe na nucleobase cytosine ifitanye isano na sugar deoxyribose. Ni igice cy'ingenzi cya ADN kandi kigira uruhare runini mu kubika no kohereza amakuru mu binyabuzima.
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Cytidine-5′-monophosphate (CMP), aside yigenga CAS:63-37-6
Cytidine 5'-monophosphate (CMP) ni nucleotide ikora nk'inkingi y'ubwubatsi bwo gukora no guhindura RNA. Ni igice cy'ingenzi mu kubaka molekile za RNA kandi igira uruhare mu bikorwa nko gufunga mRNA no gutunganya nucleus. CMP ikoreshwa kandi mu bushakashatsi bwa biochemical na molekile mu bijyanye n'ikoreshwa nko kwandika muri vitro no gushyira ibirango bya aside nucleic. Uruhare rwayo mu gutunganya RNA no kuyikoresha mu buryo butandukanye bwo kugerageza bituma iba igikoresho cy'ingenzi mu gusobanukirwa imiterere n'imikorere ya molekile za RNA.
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IBMX, 3-isobutyl-1-methylxanthine CAS:28822-58-4
3-isobutyl-1-methylxanthine, izwi kandi nka IBMX, ni methylxanthine ikomoka kuri methylxanthine ikunze gukoreshwa mu bushakashatsi bwa siyansi nk'umuti utari uwa kamere wa cyclic nucleotide phosphodiesterases. Bizwiho kongera urugero rwa cyclic AMP (cAMP) na cyclic GMP (cGMP) mu ngirabuzimafatizo mu gukumira kwangirika kwazo, ibyo bikaba bishobora guhindura inzira zitandukanye zo gutanga amakuru ku ngirabuzimafatizo.
Uretse ubushakashatsi bwayo, IBMX yakoreshejwe mu buvuzi bumwe na bumwe kubera ingaruka zayo zo kwangiza imitsi no kwangiza imitsi. Ariko, ikoreshwa ryayo mu buvuzi bw'abantu ni nkeya.
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4-Nitrophenyl phosphate disodium salt hexahydrate CAS: 4264-83-9
4-Nitrophenylphosphate disodium salt hexahydrate ni ikinyabutabire gikunze gukoreshwa mu bushakashatsi bwa biochemical na farumasi. Ni umunyu wa 4-nitrophenylphosphate, urimo iyoni ebyiri za sodium na molekile esheshatu z'amazi. Iki kinyabutabire gikunze gukoreshwa nk'ishingiro ry'ibizamini bya phosphatase no mu inyigo ya kinetics ya enzyme.
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5′-Deoxy-5-fluorocytidine CAS: 66335-38-4
5′-Deoxy-5-fluorocytidine ni ubwoko bwa nucleoside analog y’ubukorano burimo gukorwaho ubushakashatsi ku mikorere yayo yo kurwanya virusi, cyane cyane ku barwayi ba RNA nka virusi ya hepatite C (HCV) na flavivirusi. Ikora mu kubangamira ukwiyongera kw'uturemangingo tw’uturemangingo twa virusi, amaherezo ikabuza virusi ubushobozi bwo kugwira no gukwirakwira mu mubiri.
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Cytidine-5′-triphosphate (CTP), umunyu wa disodium CAS: 652154-13-7
Cytidine-5′-triphosphate (CTP), umunyu wa disodium ni triphosphate ya nucleoside ikora nk'inkingi y'ubwubatsi bwo gukora RNA. Igira uruhare runini mu gukora imikorere y'uturemangingo kandi ni ingenzi mu kohereza amakuru ya genetiki kuva kuri ADN kugera kuri RNA mu gihe cyo kwandika. CTP ikoreshwa cyane mu bushakashatsi ku binyabuzima bya molekile, cyane cyane mu bushakashatsi bujyanye no gukora RNA, kwivanga kwa RNA, n'izindi nzira zijyanye na RNA. Byongeye kandi, ikoreshwa mu bikorwa bya enzyme, inyigo ku gukora imikorere ya nucleotide, ndetse no nk'ishingiro ry'ibizamini bitandukanye bya biochemical. Mu nganda zikora imiti, CTP ishobora kandi gukoreshwa mu guteza imbere imiti irwanya virusi na kanseri.
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ITP, inosine 5′-triphosphate trisodium umunyu CAS: 35908-31-7
Umunyu wa Inosine-5′-triphosphate trisodium, ukunze kuvugwa mu magambo make nka ITP-Na3, ni ubwoko bwa inosine ya triphosphate, ni ukuvuga nucleoside igira uruhare runini mu mikorere itandukanye ya biyoloji. Iki kinyabutabire ni umunyu, bigatuma gishonga mu mazi kandi kikaba gikwiriye gukoreshwa mu isuzuma rya biochemical na enzymatic, ndetse no mu bushakashatsi ku binyabuzima bya molekile. Umunyu wa Inosine-5′-triphosphate trisodium ukoreshwa mu kwiga uburyo enzymatic ikora, interconversion ya nucleotide, ndetse no nk'umusemburo w'imisemburo imwe n'imwe. Ikoreshwa ryayo rinagera no ku nyigo za analog za nucleotide ndetse no mu gutegura uruvange rwa nucleotide rukoreshwa mu buhanga bwa molekile.
