Tofacitinib CAS: 477600-75-2 Umukozi Ukora

Tofacitinib ni umuti uvura indwara ya rubagimpande (RA), psoriasis, indwara y’amara abyimba, n’izindi ndwara z’ubudahangarwa bw’umubiri, ndetse no gukumira kwangwa kw’ingingo. Ni umuti ubuza enzyme Janus kinase 3 (JAK3), bivuze ko ibangamira inzira y’ibimenyetso ya JAK-STAT yohereza amakuru hanze y’akaremangingo mu gice cy’ingirabuzimafatizo, bigira ingaruka ku ihindurwa rya ADN. Vuba aha byagaragaye mu buryo bwa murine bwa rubagimpande bwamaze kugaragara, tofacitinib yazamuye indwara vuba binyuze mu kubuza ikorwa ry’ibintu bitera ububyimbirwe no guhagarika gene zishingiye kuri STAT1 mu ngingo. Ubu buryo bwiza muri ubu buryo bw’indwara bwahujwe no kubuza inzira zombi za JAK1 na 3, bigaragaza ko tofacitinib ishobora kugira akamaro mu kuvura binyuze mu nzira zitari izo gukumira JAK3 gusa.