Spironolactone CAS: 52-01-7 Umukozi Ukora

Spironolactone (Aldactone) ni ikintu cyakozwe bwa mbere nk'umurwanya wa mineralocorticoid kandi gikoreshwa nk'umuti ugabanya umuvuduko w'amaraso n'umuvuduko w'amaraso. Ariko, iyo spironolactone ikoreshejwe ku rugero rwo hejuru ifatana na androgen receptor. Mu buvuzi, ni umurwanya wa androgen udakomeye ukoreshwa mu kuvura hirsutism ku bagore binyuze mu kubuza testosterone gufatana na androgen receptors mu dusatsi. Gukoresha spironolactone ku bagore mu kuvura hirsutism cyangwa ububabare bw'abagabo bishobora gutuma urugero rwa potasiyumu mu maraso ruzamuka; uru rugero rugomba kugenzurwa mu kwezi kumwe uhereye igihe watangiriye gufata umuti. Spironolactone (Aldactone) ifitanye isano na aldosterone mu miterere yayo kandi ikora nk'umuti urwanya guhangana kugira ngo wirinde ko aldosterone ifatana na poroteyine yayo yihariye ifatana.