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N, N-Bis (2-hydroxyethyl) -2-aminoethanesulfonic acide sodium umunyu CAS: 66992-27-6
N.Ifasha kugumana urwego ruhamye rwa pH, bigatuma biba byiza mubikorwa nkumuco wimikorere, insimburangingo ya enzyme, ubushakashatsi bwa poroteyine, electrophorei, hamwe nubuvuzi bwa farumasi.HEPES umunyu wa sodiumi itanga uburyo bwiza bwibinyabuzima kandi bikongerera ukuri no kwizerwa ibisubizo byubushakashatsi.
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2 ′ - (4-METHYLUMBELLIFERYL) -ALPHA-DN-ACETYLNEURAMINIC ACID SODIUM SALT CAS: 76204-02-9
2 ′ - (4-Methylumbelliferyl) -alpha-DN-acetylneuraminic acide sodium yumunyu ni imiti yimiti ikoreshwa muburyo bwo gusuzuma no gukora ubushakashatsi.Ni fluorescente yanditseho inkomoko ya acide sialic, ubwoko bwa molekile ya karubone ya hydrata iboneka hejuru ya selile.
Uru ruganda rukoreshwa nka substrate ya enzymes yitwa neuraminidase, ikora kugirango ikureho ibisigazwa bya acide sialic muri glycoproteine na glycolipide.Iyo iyi misemburo ikora kuri 2 ′ - (4-Methylumbelliferyl) -alpha-DN-acetylneuraminic acide sodium umunyu, irekura ibicuruzwa bya fluorescent bizwi nka 4-methylumbelliferone.
Florescence ikorwa nuruvange irashobora gupimwa no kugereranywa, igatanga amakuru kubikorwa bya enzymes ya neuraminidase.Ibi ni ingirakamaro cyane cyane mukwiga indwara zitandukanye nuburyo bujyanye na aberrant sialic aside metabolism.
Uru ruganda rukoreshwa kandi muburyo bwo gusuzuma, nko mugushakisha kwandura virusi zirimo ibikorwa bya neuraminidase.Muri ubu bushakashatsi, urugimbu rukoreshwa mu kwerekana ko hari virusi yihariye cyangwa gusuzuma imikorere ya neuraminidase inhibitor mu kuvura virusi.
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TAPSO CAS: 68399-81-5 Igiciro cyabakora
TAPSO (3-Nibikoresho bikora neza hamwe na pKa hafi ya pH physiologique pH, bigatuma ikomeza kubungabunga pH ihamye mubushakashatsi bwibinyabuzima.TAPSO ikoreshwa kenshi mugusukura poroteyine, gusesengura enzyme, umuco w'akagari, hamwe na electrophoreis.Amazi menshi yo gukama no kutivanga muburyo bwibinyabuzima bituma ahitamo gukundwa mubumenyi bwa siyanse.TAPSO izwiho ingaruka nkeya kubikorwa bya enzyme kandi ikoreshwa kenshi mubindi bisubizo nka Tris cyangwa fosiferi.
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N-Acetyl-L-cysteine CAS: 616-91-1
N-Acetyl-L-cysteine (NAC) ni uburyo bwahinduwe bwa sisitemu ya amine aside.Itanga isoko ya sisitemu kandi irashobora guhinduka byoroshye muri tripeptide glutathione, antioxydants ikomeye mumubiri.NAC izwiho kurwanya antioxydeant na mucolytike, ikagira akamaro mubikorwa bitandukanye byubuzima.
Nka antioxydeant, NAC ifasha kurinda selile kwangirika kwatewe na radicals yubusa, ubwoko bwa ogisijeni ikora, nuburozi.Ifasha kandi synthesis glutathione, igira uruhare runini mubikorwa byo kwangiza umubiri no kubungabunga umubiri.
NAC yakozweho ubushakashatsi ku nyungu zishobora kugira mu buzima bw’ubuhumekero, cyane cyane ku bantu bafite ibibazo nka bronhite idakira, COPD, na fibrosis ya cystic.Bikunze gukoreshwa nkibisohoka kugirango bifashe kunanuka no koroshya urusenda, byoroshye guhanagura inzira.
Byongeye kandi, NAC yerekanye amasezerano yo gushyigikira ubuzima bwumwijima ifasha mugukuraho ibintu byuburozi, nka acetaminofeni, igabanya ububabare busanzwe.Irashobora kandi kugira ingaruka zo gukingira kwangirika kwumwijima guterwa no kunywa inzoga.
Usibye imiterere ya antioxydeant nubuhumekero, NAC yashakishijwe ku nyungu zishobora kugira mu buzima bwo mu mutwe.Ubushakashatsi bumwe bwerekana ko bushobora kugira ingaruka nziza ku ihungabana ry’imyumvire, nko kwiheba no guhungabana bikabije (OCD).
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PIPES CAS: 5625-37-6 Igiciro cyabakora
PIPES (piperazine-1,4-bisethanesulfonic aside) ni uruganda rwa zwitterionic rukoreshwa cyane mubushakashatsi bwibinyabuzima na biohimiki.Nibikorwa byiza bya pH bifite ubushobozi buke bwo kubungabunga imiterere ihamye ya pH murwego rwa pH ya 6.1 kugeza 7.5.PIPES ifite intera ntoya na biomolecules kandi irakwiriye kubushakashatsi bushingiye ku bushyuhe.Bikunze gukoreshwa mubuhanga bwa gel electrophorei no gukora imiti nkumuti uhoraho.Muri rusange, PIPES ni ibintu byinshi kandi bikoreshwa cyane mubice bitandukanye byubushakashatsi.
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2 ′, 6′-DiMethylcarbonylphenyl-10-sulfopropylacridiniuM-9-carboxylate 4′-NHS Ester CAS: 194357-64-7
2,Irimo itsinda rya sulfopropylacridinium hamwe na carboxylate ester ikora.Kubaho kwa ester moiety byerekana ko idakora kandi irashobora gukoreshwa nkibimenyetso cyangwa guhindura ibintu kuri biomolecules.
Itsinda rya sulfopropylacridinium ryerekana ko rishobora kuba rishobora gukoreshwa mubushakashatsi bushingiye kuri fluorescence, aho bushobora gukoreshwa nka probe ya fluorescent cyangwa irangi mugushakisha no gusesengura biomolecules.Irashobora kandi kugira akamaro mubushakashatsi bwibikorwa bya selile, nka calcium yo mu nda.
Kwinjizamo itsinda rya NHS ester ryerekana ko rishobora kwitwara hamwe na amine yambere, nkibisangwa muri poroteyine cyangwa peptide, kugirango bibeho neza.Iyi reaction ituma iba ingirakamaro kuri porogaramu ya bioconjugation, aho ishobora gukoreshwa mu kuranga cyangwa guhindura biomolecules hamwe nizindi molekile zikora, nka fluorophores cyangwa tagi.
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5-Bromo-4-chloro-3-indolyl-N-acetyl-beta-D-glucosaminide CAS: 4264-82-8
5-Bromo-4-chloro-3-indolyl-N-acetyl-beta-D-glucosaminide nuruvange rukoreshwa mubushakashatsi butandukanye bwibinyabuzima, cyane cyane mugushakisha no kubona amashusho yibikorwa bya enzyme.Ni substrate ishobora kuba hydrolyz na enzymes zihariye, bikavamo kurekura ibicuruzwa byamabara cyangwa fluorescent.
Uru ruganda rusanzwe rukoreshwa mubushakashatsi kugirango hamenyekane ahari nibikorwa bya enzymes nka beta-galactosidase na beta-glucuronidase.Iyi misemburo ikuramo amatsinda ya acetyl na glucosaminide kuva muri substrate, biganisha kuri chromofore yubururu cyangwa icyatsi.
Imiterere yihariye ya 5-Bromo-4-chloro-3-indolyl-N-acetyl-beta-D-glucosaminide itanga uburyo bworoshye bwo kumenya no kugereranya ibikorwa bya enzyme.Gukoresha muburyo butandukanye bwubushakashatsi, harimo histochemie, immunohistochemie, hamwe nubushakashatsi bushingiye ku ngirabuzimafatizo, byagize uruhare mu gusobanukirwa neza imikorere ya enzyme.
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Umunyu wa Sodium Umunyu CAS: 139-41-3 Igiciro cyabakora
N, N-Bis (2-hydroxyethyl) umunyu wa sodium ya glycine ni uruganda rwimiti rukoreshwa nkibikoresho byo mu bwoko bwa biohimiki na biofiziki.Ifasha kugumana urwego pH ruhamye mubihe byubushakashatsi, bikagira akamaro mubushakashatsi bwa enzyme, ubushakashatsi bwa poroteyine, umuco w'utugari, hamwe na tekinoroji yo guhuza iburengerazuba.
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Spinosad CAS: 131929-60-7 Utanga ibicuruzwa
Spinosad nitsinda 5 nicotinic acetylcholine reseptor agonist, itera kugabanuka kwimitsi itabishaka no guhinda umushyitsi kugeza kuri moteri ya neuron.Kumara igihe kinini bitera ubumuga no gupfa.Urupfu rwa Flea rutangira muminota 30 yo kunywa kandi mumasaha 4 rwuzuye.Spinosad ntishobora gukorana nimbuga zihuza izindi miti yica udukoko (GABA-ergic cyangwa nicotinic).
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Rotenone CAS: 83-79-4 Utanga ibicuruzwa
Rotenone ni igifu kandi ni uburozi bwa arthropods.Igikorwa cyacyo cyihuta cyatewe no kugabanya kuboneka kwa nikotinamide adenine dinucleotide kugirango ibe cofactor mumihanda itandukanye ya biohimiki harimo na Krebs cycle, bityo bikabuza imisemburo ya myiteguro ya mitochondial.
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Diazinon CAS: 333-41-5 Utanga ibicuruzwa
Diazinon iraboneka muburyo bwamazi atagira ibara cyangwa yijimye.Irashobora gushonga gake mumazi ariko irashonga cyane muri peteroli ether, inzoga, na benzene.Diazinon ikoreshwa muguhashya ubuhinzi butandukanye nudukoko twangiza murugo.Muri byo harimo udukoko twangiza mu butaka, ku bimera by'imitako, imbuto, imboga, n'ibihingwa hamwe n'udukoko two mu rugo nk'isazi, ibihuru, n'inkoko.
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Avermectin CAS: 71751-41-2 Utanga ibicuruzwa
Abamectin (Avermectin) ni ibintu byangiza ubumara.Uburyo bwayo bwibanda kuri GABAA yakira udukoko twangiza udukoko twa neuron cyangwa synaps ya neuromuscular, bikabangamira ihererekanyamakuru ry’imitsi iva mu mitsi, aribyo gukangurira imitsi ya neurotransmitter inhibitor γ-aminobutyric aside (GA-BA), bigatuma hafungurwa cyane GABA-yashizwemo umuyoboro wa chloride hamwe ningaruka ya chloride.
