Letrozole CAS: 112809-51-5 Utanga ibicuruzwa

Letrazole irashobora guhuzwa mubyiciro bibiri kuva 4- bromomethyl-benzonitrile hamwe na 1,2,4-triazole kandi ni igisekuru cya gatatu inhibitori ya aromatase.Ninzitizi yihariye ya P450arom irinda ihinduka rya androstenedione kuri estrone.Kugabanuka kwa plasma estrogene byahise kandi birebire.Ibi bigerwaho nta kubuza izindi steroid biosynthesis bigatuma iba aromatase inhibitor yapimwe cyane.Letrazole ifite ibikorwa bidasanzwe bya antitumor, irihanganirwa kandi nta ngaruka mbi zifite.Ifite imbaraga 10,000 10,000 kurusha aminoglutethimide, muri vivo, inhibitor ya aromatase ya mbere yashizweho neza.