Huperzine A 1 CAS: 102518-79-6 Umukozi Ukora

Huperzine A ni umuti mushya wo kuvura indwara zo kwibuka zitari mbi zishobora gukumira indwara zo mu bwonko mu bantu bo mu kigero cyo hagati n’abageze mu za bukuru, kugarura imikorere y’imitsi yo mu bwonko, no gukora neurotransmitters zo mu bwonko. Huperzine A ntabwo ibuza gusa imikorere ya cholinesterase, ahubwo inanoza imikorere y’ubwonko n’ubushobozi bwo kwiga no kwibuka binyuze mu buryo butandukanye bw’imiti nko kugira ingaruka ku buryo bwa radicals yigenga, kugabanya urugero rw’imvugo ya somatostatin, urwego rw’imyakura [Ca2+], aside glutamic no kongera calmodulin (CaM) na calmodulin messenger RNA (CaM mRNA). Huperzine A ni umuti ushobora kuvura indwara ya Alzheimer igabanya alkaloid ibuza AChE kwambuka umupaka w’amaraso n’ubwonko. Igabanya urupfu rw’uturemangingo ruterwa na glutamate mu mico y’ibanze ikomoka ku bwonko bwo mu mutwe, hippocampus, cortex na cere.