Glucose-6-Fosfati Dehydrogenase CAS:9001-40-5

Ihinduka ry’uturemangingo: G6PD igira uruhare mu mikorere y’isukari, cyane cyane inzira ya pentose phosphate. Ituma glucose-6-phosphate ihinduka 6-phosphogluconolactone, bigatuma NADPH ihinduka. NADPH ni molekile y’ingenzi mu mikorere itandukanye y’uturemangingo, harimo kurinda antioxidant, gukora aside irike na cholesterol, no kubungabunga uburyo bwo guhuza uturemangingo.

Ubwirinzi bwa Antioxydants: NADPH ikorwa na G6PD ni ingenzi cyane mu gukora glutathione (GSH) yagabanutse, molecule y’ingenzi ya antioxydants. GSH irinda uturemangingo ku mvune za oxidants binyuze mu kugabanya uturemangingo tw’umwuka duto (free radicals) n’ubwoko bwa ogisijeni (REACTIONS). Kubura G6PD bishobora kwangiza iboneka rya NADPH no kugabanya ubushobozi bwo kwirinda antioxydants, bigatuma habaho kwangirika kwa oxidants.

Anemia yo mu maraso: Kubura G6PD ni cyo kibazo gikunze kugaragara ku isi hose ku buntu. Gikunze kwibasira abagabo kandi gishobora gutera indwara yo kubura amaraso yo mu maraso, indwara irangwa no kwangirika kw'uturemangingo dutukura tw'amaraso. Hari ibintu bimwe na bimwe bitera, nk'indwara zandura, imiti imwe n'imwe (urugero: imiti yo kurwanya malariya, imiti ya sulfa), n'ibiribwa bimwe na bimwe (urugero: ibishyimbo bya fava), bishobora gutera kubura amaraso mu bantu bafite ikibazo cyo kubura G6PD. Kubura G6PD bituma umuntu adashobora guhangana n'ikibazo cya oxidative giterwa n'ibi bintu, bigatuma uturemangingo dutukura two mu maraso tugabanuka.

Ubuvuzi bw'imiti: Gusuzuma G6PD ni ingenzi mu buvuzi bw'imiti kugira ngo hirindwe ingaruka mbi ku miti. Imiti imwe n'imwe, nka malariya imwe n'imwe (urugero, primaquine) na antibiyotike (urugero, sulfonamides), ishobora gutera hemolysis ku bantu bafite ikibazo cyo kubura G6PD. Gusuzuma mbere y'uko G6PD ibura bifasha mu kumenya abantu bari mu kaga kandi bishobora kuyobora amahitamo y'imiti cyangwa ikoreshwa ry'ubundi buryo bwo kuvura kugira ngo hirindwe indwara zikomeye zo kubura amaraso.