Boc-Leu-ONp CAS:3350-19-4

Boc-Leu-ONp ikoreshwa cyane mu ngamba zo guhuza ibinyabuzima n'uburyo bwo guhindura peptide. Mu gukora peptide, ituma ibisigazwa bya leucine bigenzurwa byinjizwa mu buryo bugenzurwa mu buryo bwa peptide, bigatuma amatsinda atandukanye y'imikorere, ibirango, cyangwa molekile bishyirwa mu bikorwa bitandukanye. Uku guhindura ibintu mu buryo butoranijwe byoroshya ikorwa rya peptide zifite imikorere myinshi zifite imiterere yihariye, nko kongera ubushobozi bwo guhagarara, ubushobozi bwo gushushanya ibintu, cyangwa ubushobozi bwo gufata amashusho. Mu bushakashatsi bwa poroteyine, Boc-Leu-ONp yemerera gushyira poroteyine na peptide mu buryo bwihariye, bigatanga umusanzu mu gusesengura imiterere, inyigo z'imikoranire, n'igerageza rishingiye kuri spectrometry y'ubwinshi. Gushyira Boc-Leu-ONp mu buryo bugenzurwa mu buryo bugenzurwa bituma habaho imiterere nyayo n'isesengura ry'imikorere ya poroteyine na peptide, bishyigikira iterambere mu gusobanukirwa sisitemu y'ibinyabuzima n'uburyo indwara zigenda. Byongeye kandi, mu iterambere ry'imiti, Boc-Leu-ONp igira uruhare runini mu guhuza imiti ivura na peptide cyangwa poroteyine, irema sisitemu yo gutanga imiti yihariye, antibody-drug conjugates, cyangwa inkingo zifite imiterere myiza ya pharmacokinetic kandi zikagabanya ingaruka zitari izo. Muri make, ubwizerwe n'ubushobozi bwo guhindura peptide no guhuza imiterere y'umubiri (bioconjugation) bya Boc-Leu-ONp bituma iba igikoresho cy'ingenzi mu guteza imbere ubushakashatsi mu kuvumbura imiti, ibinyabuzima by'ibinyabutabire, na proteomics, bitanga amahirwe atandukanye yo guteza imbere uburyo bushya bwo gukoresha imiti.