Boc-D-MeLeu-OH CAS: 89536-84-5

Boc-D-MeLeu-OH ikoreshwa cyane mu gukora peptide ikoze mu buryo bwa solid-phase kugira ngo hakorwe peptide zakozwe ku buryo bwihariye zifite uruhererekane n'imikorere yihariye. Nk'uburyo burinzwe bwa DN-methyl-leucine, yemerera ko ibisigazwa bya DN-methyl-leucine byinjizwa mu ruhererekane rwa peptide rukura, bikarinda ingaruka mbi zitifuzwa kandi bigafasha gukora peptide zikomeye zifite imiterere yihariye. Mu bijyanye no guhuza ibinyabuzima n'ibinyabuzima, Boc-D-MeLeu-OH ikora nk'inkingi ikomeye yo gukora peptide zikora ku mubiri, imashini zigaragaza amazina, n'imiti ishingiye kuri peptide. Ikoreshwa ryayo rituma habaho guhindura neza peptide na poroteyine, byoroshya iterambere rya molecules nyinshi zifite ubushobozi bwo guhagarara neza, ubushobozi bwo gushushanya ibintu bitandukanye mu buvuzi. Byongeye kandi, mu kuvumbura imiti no guteza imbere ubuvuzi, Boc-D-MeLeu-OH ikoreshwa mu gukora peptide conjugates na peptides zahinduwe zifite imiterere myiza ya pharmacokinetic n'ibikorwa bya biyoloji. Izi mpinduka zishobora kongera imikorere, guhitamo, no gutanga imiti ishingiye kuri peptide, bigafasha mu iterambere mu buvuzi bunoze no mu buryo bwo kuvura bwibanda ku buryo bufatika. Muri rusange, ubwizerwe bwa Boc-D-MeLeu-OH no kuba ikora neza mu guhuza peptide n'uburyo ihuza ibinyabuzima bituma iba igikoresho cy'ingenzi mu guteza imbere ubushakashatsi mu kuvumbura imiti, ibinyabuzima by'ibinyabutabire, na proteomics, bitanga amahirwe atandukanye yo guteza imbere uburyo bushya bwo gukoresha imiti.