Boc-Ile-ONp CAS:16948-38-2

Boc-Ile-ONp ikoreshwa cyane mu ngamba zo guhuza ibinyabuzima n'uburyo bwo guhindura peptide. Mu gukora peptide, byoroshya uburyo ibisigazwa bya isoleucine byinjizwa mu buryo bugenzurwa mu buryo bugenzurwa, bigatuma amatsinda atandukanye y'imikorere, ibirango, cyangwa molekile zikoreshwa mu buryo butandukanye. Ubu buryo bwo guhindura ibintu butuma habaho peptide nyinshi zifite imiterere yihariye, nko kongera ubushobozi bwo guhagarara, ubushobozi bwo gushushanya, cyangwa ubushobozi bwo gufata amashusho. Mu bushakashatsi bwa poroteyine, Boc-Ile-ONp ituma poroteyine na peptide zishyirwa mu buryo bwihariye, bigatanga umusanzu mu gusesengura imiterere, inyigo z'imikoranire, n'igerageza rishingiye kuri spectrometry y'ubwinshi. Gufata Boc-Ile-ONp mu bisigazwa bya isoleucine byoroshya imiterere nyayo n'isesengura ry'imikorere ya poroteyine na peptide, bishyigikira iterambere mu gusobanukirwa sisitemu y'ibinyabuzima n'uburyo indwara zigenda. Byongeye kandi, mu iterambere ry'imiti, Boc-Ile-ONp igira uruhare runini mu guhuza imiti ivura na peptide cyangwa poroteyine, irema sisitemu yo gutanga imiti yihariye, antibody-drug conjugates, cyangwa inkingo zifite imiterere myiza ya pharmacokinetic kandi zikagabanya ingaruka zitari izo. Muri rusange, kuba Boc-Ile-ONp yizewe kandi ikora neza mu guhindura peptide no guhuza imiterere y’umubiri bituma iba igikoresho cy’ingenzi mu guteza imbere ubushakashatsi mu kuvumbura imiti, ibinyabuzima by’ibinyabutabire, na proteomics, bitanga amahirwe atandukanye yo guteza imbere uburyo bushya bwo gukoresha imiti.