Asetilikolini iyode CAS:1866-15-5

Iyode ya Acetylthiocholine ikoreshwa cyane cyane nk'igice cyo gupima imikorere ya enzyme acetylcholinesterase (AChE). AChE ni yo ishinzwe gusenya acetylcholine y'imitsi mu mitsi. Kongeramo iyode ya acetylthiocholine mu ruvange rw'ibisubizo rurimo AChE bituma habaho thiocholine na acetate.

Iyo reaction ishobora kumenyekana wongeyeho ikimenyetso cya colorimetric cyangwa fluorometric gikorana na thiocholine by'umwihariko. Igipimo cy'umusaruro w'amabara cyangwa fluorescence gihuye neza n'imikorere ya AChE mu gipimo. Ibi bituma acetylthiocholine iyoodide iba igikoresho cy'ingirakamaro cyo gupima imikorere ya AChE mu bipimo bitandukanye by'ibinyabuzima, harimo ingirabuzimafatizo, uturemangingo tw'uturemangingo, n'amaraso.

Gupima imikorere ya AChE hakoreshejwe iyode ya acetylthiocholine bikoreshwa cyane mu bushakashatsi bujyanye n'imikorere ya cholinergic, indwara zo mu bwonko, no guhura n'ibinyabutabire cyangwa imiti imwe n'imwe ishobora kugira ingaruka ku mikorere ya AChE. Bishobora kandi gukoreshwa nk'igikoresho cyo gusuzuma mu gupima imiti ibuza AChE, ishishikajwe no guteza imbere imiti ku ndwara nka Alzheimer na Parkinson.

Uretse gukoreshwa mu isuzuma rya enzymatic, iyode ya acetylthiocholine ishobora no gukoreshwa nk'ishingiro ry'ibikoresho by'ibinyabuzima bishingiye kuri AChE. Ibi bikoresho by'ibinyabuzima byagenewe gupima no gupima niba hari ibintu bimwe na bimwe bishobora kubuza imikorere ya AChE, nk'imiti yica udukoko ya organophosphate cyangwa imiti itera imitsi.