Tofacitinib CAS: 477600-75-2 Utanga ibicuruzwa

Tofacitinib ni umuti wo kuvura rubagimpande ya rubagimpande (RA), psoriasis, indwara zifata amara, nizindi ndwara zikingira indwara, ndetse no gukumira kwangwa kwimura ingingo.Nibibuza enzyme Janus kinase 3 (JAK3), bivuze ko ibangamira inzira yerekana ibimenyetso JAK-STAT itanga amakuru hanze yakagari muri selile selile, bikagira ingaruka kuri ADN.Vuba aha, byerekanwe muburyo bwa murine bwa arthrite yashyizweho, tofacitinib yateje imbere indwara byihuse mu guhagarika umusaruro w’abunzi batera umuriro no guhagarika ingirabuzima fatizo ziterwa na STAT1 mu ngingo zifatanije. Izi ngaruka muri ubu buryo bw’indwara zifitanye isano no kubuza JAK1 na 3 ibimenyetso byombi. inzira, byerekana ko tofacitinib ishobora gukoresha inyungu zo kuvura binyuze munzira zidasanzwe zo kubuza JAK3.