Sodium Alpha-Ketoisocaproate CAS: 4502-00-5 Umukozi Ukora

Sodium Alpha-Ketoisocaproate ni metabolite ya leucine izwiho gutuma insuline isohoka mu turemangingo twa β twa pancreas. Gutera aα-Ketoisocaproate mu nda byagaragaye ko byoroshya imiterere y’uturemangingo. Imibiri ya ketone ivamo ihinduka ishobora kuba isoko y’ingufu. Kwiyongera kwa aside α-Ketoisocaproic kurangwa muri ketoaciduria y’uruhererekane rw’amashami, iterwa no kubura imikorere ya L-2-keto acid dehydrogenase mu ruhererekane rw’amashami. Aside α-Ketoisocaproic itera kwitandukanya mu buryo bwa oxidative phosphorylation kandi igakora nk'inzitizi ya metabolism ya α-ketoglutarate dehydrogenase. Bityo, biganisha ku ntege nke muri mitochondrial homeostasis, igaragara muri ketoaciduria y’uruhererekane rw’amashami.