Simvastatin CAS: 79902-63-9 Umukozi Ukora

Simvastatin ni ikoze mu buryo buciriritse, ikunda cyane hydrophobic, imeze nka lovastatin. Kimwe na lovastatin, simvastatin ni igabanya HMG-CoA reductase kandi ikoreshwa mu kuvura kugira ngo igabanye cholesterol ya LDL. Vuba aha, statins yabaye ubushakashatsi bw'ingenzi mu binyabuzima mu ngirabuzimafatizo. Uruhare rwazo mu bintu byinshi rushobora gushingira ku buryo bw'ibanze bw'imikorere yazo, ariko, uburyo zikoramo izindi ngaruka nyinshi ntizigaragara cyane. Simvastatin ni igabanya HMG-CoA reductase, enzyme ihindura HMG-CoA muri mevalonate, intambwe ya mbere mu gukora cholesterol. Ikoreshwa mu kuvura hypercholesterolemia, kuko igabanya urugero rwa lipoproteins nke na triglycerides, kandi ikongera urugero rwa lipoproteins nyinshi.