Puromycin dihydrochloride CAS: 58-58-2 Igiciro cy'umukozi

Puromycin dihydrochloride ni umuti ukomeye ukoreshwa cyane mu bushakashatsi ku binyabuzima bya molekile no ku binyabuzima by’uturemangingo. Ibuza poroteyine gukora itera guhagarika ikorwa rya poroteyine itaratangira mu gihe cyo guhindura. Puromycin ikora igana impera ya metero 3 z'umusemburo wa tRNA ugizwe na aminoacylated hanyuma ikazanwa mu ruhererekane rw'iporoteyine rukura. Ibi bituma poroteyine igabanuka kandi amaherezo igahagarika ikorwa ry'ihindurwa.

Uburyo nyamukuru bwo gukoresha puromycin dihydrochloride ni uguhitamo no gutandukanya uturemangingo twahinduwe cyangwa twashyizwemo gene yo kurwanya puromycin. Ibi bigerwaho binyuze mu kwinjiza gene ishimishije hamwe na gene yo kurwanya puromycin mu turemangingo, hanyuma tukayikoresha mu kuvura puromycin. Uturemangingo twabashije gushyira gene yo kurwanya puromycin muri gene yabo ni two gusa tuzarokoka kandi tukororoke, bigatuma uturemangingo twifuza dutoranywa kandi tugatandukanywa.

Puromycin dihydrochloride ikoreshwa kandi mu bushakashatsi bujyanye no kugaragaza ingirabuzima fatizo no gukora poroteyine. Mu kubuza gukora poroteyine, ishobora gufasha abashakashatsi kwiga uburyo poroteyine zikorwamo, kumenya poroteyine zikorwa vuba bitewe n’ibintu bimwe na bimwe, no gusesengura uburyo zikorwamo.

Byongeye kandi, puromycin dihydrochloride ikoreshwa mu gukora imirongo ihamye y’uturemangingo hamwe n’impinduka zihariye mu ngirabuzimafatizo. Mu gushyiramo gene irwanya puromycin hamwe n’impinduka mu ngirabuzimafatizo, abashakashatsi bashobora gukora imirongo y’uturemangingo igaragaza neza gene ishimishije n’impinduka mu ngirabuzimafatizo. Ibi bituma habaho inyigo z’igihe kirekire no kugaragaza imikorere y’uturemangingo.