PhentolamineMesylate CAS:65-28-1

Phentolamine mesylate ifite uruhare runini mu buvuzi no mu bushakashatsi. Nk'umuti ukomeye wo koroshya imitsi no kurwanya umuvuduko ukabije w'amaraso, ikoreshwa mu kuvura ibibazo byihutirwa by'umuvuduko ukabije w'amaraso, cyane cyane mu bihe by'ikibazo cya pheochromocytoma, aho kugabanya umuvuduko w'amaraso byihuse ari ngombwa. Igira kandi akamaro mu kuvura indwara ziterwa na catecholamine iterwa na iatrogenic mu gihe cyo kubaga no mu bundi buryo bw'ubuvuzi. Mu buvuzi bw'amenyo, phentolamine mesylate ikoreshwa nk'umuti ugabanya ububabare mu gace, ifasha mu gucunga ikinya cyoroshye cy'imitsi nyuma yo gukora imiti yo mu gace irimo vasoconstrictor nka epinephrine. Ingaruka zayo zo koroshya imitsi zifasha mu kugabanya umuvuduko w'amaraso mu gace no kwihutisha kugarura amaraso mu buryo busanzwe. Byongeye kandi, iyi miti ikoreshwa mu buryo bwo gusuzuma nko gukumira no kuvura indwara ya dermal necrosis iterwa no gusohora imiti ikora ku mubiri, kwemeza ko ikora neza mu mubiri. Byongeye kandi, igira uruhare mu bushakashatsi no mu igeragezwa ry'ubuvuzi risuzuma uburyo ishobora gukoreshwa mu ndwara zijyanye no kubura imitsi, kudakora neza kw'imitsi, no mu ndwara ya Raynaud, bigira uruhare mu iterambere mu buvuzi bw'umutima n'urwungano ngogozi. Uruhare rwa Phentolamine mesylate rugera no ku igerageza nk'igikoresho mu bushakashatsi bw'imiti n'ubw'umubiri, rufasha mu iperereza ku mikorere ya adrenergic receptor, uburyo imitsi ikora, no guhindura imikorere y'imitsi ikora neza. Ubushobozi bwayo bwo guhagarika adrenergic receptor no kugira ingaruka ku mitsi y'amaraso bufasha mu gusobanukirwa imikorere y'umutima n'imitsi no guteza imbere uburyo bwo kuvura bugamije inzira zo gutanga ibimenyetso bya adrenergic. Muri rusange, uburyo butandukanye phentolamine mesylate ikoresha bugaragaza akamaro kayo mu buvuzi bw'indwara, ubuvuzi bw'amenyo, ubushakashatsi, n'iterambere ry'imiti, bishimangira ubushobozi bwayo bwo kugira uruhare mu micungire myiza y'indwara z'umutima no guteza imbere ubumenyi bwa siyansi bujyanye n'imikorere ya adrenergic receptor no kugenzura imitsi y'amaraso.