Nigericin CAS: 28380-24-7

Nigericin yakoreshejwe cyane muri laboratwari z’ubushakashatsi mu kwiga uburyo bwo gutwara iyoni mu turemangingo, kugenzura ubushobozi bwa membrane, no guhindura pH mu turemangingo. Imiterere yayo ya ionophoric ituma iba igikoresho cy'ingirakamaro mu gushakisha inzira zo gutanga ibimenyetso bya iyoni, kwinjira mu turemangingo, no guhagarara k'uturemangingo. Abashakashatsi bakunze gukoresha nigericin mu guhindura ingano ya iyoni mu turemangingo no gusesengura ingaruka zayo ku mikorere n'ubushobozi bw'uturemangingo. Uretse ikoreshwa ryayo mu bushakashatsi, nigericin yagaragaje imiterere myiza yo kurwanya kanseri binyuze mu gutuma apoptosis (urupfu rw’uturemangingo rwateguwe) mu turemangingo twa kanseri. Ubushakashatsi bwagaragaje ubushobozi bwa nigericin bwo kubuza gukura kw'uturemangingo twa kanseri, gutera imikorere mibi ya mitochondrial, no kubangamira inzira zo gutanga ibimenyetso bya kanseri. Ibi byavumbuwe bigaragaza ko nigericin ishobora gukoreshwa nk'umuti uvura ubwoko bumwe na bumwe bwa kanseri, bigaragaza uruhare rwayo mu bushakashatsi bwa kanseri no guteza imbere imiti. Nubwo nigericin ifite icyizere mu bushakashatsi bwa siyansi n'ubushakashatsi bwa kanseri, imikorere yayo ikomeye mu binyabuzima isaba kuyifata neza no kuyigenzura mu duce twa laboratwari. Abashakashatsi bakorana na nigericin bagomba gukurikiza amabwiriza n'amabwiriza y'umutekano kugira ngo barebe ko icungwa neza kandi igatabwa. Gukorana n'inzobere z'inararibonye no gukurikiza uburyo busanzwe ni ingenzi mu gihe ukoresha nigericin mu bushakashatsi cyangwa ushakisha ubushobozi bwayo bwo kuvura mu buryo butandukanye bwo mu rwego rw'ubuvuzi.