Reagent ya Neocuproine ni reagent yo kumenya umuringa, kristu y'umweru cyangwa umuhondo, irakaza. Ikoreshwa cyane cyane nk'ireagent yo kumenya umuringa, ipima isukari yo mu maraso, ipima isukari yo mu maraso ikabije; organic synthesis. Neocuproine hydrochloride monohydrate yakoreshejwe mu gupima ishonga ry'umuringa muri Cu-Ni alloys hakoreshejwe uburyo bwa colorimetric. Yanakoreshejwe mu gutegura umuti wa complexing agent mu kwiga ibizamini by'ubushobozi bwa antioxydant mu bipimo bya biological hashingiwe ku misozo yo kugabanya Cu. Ishobora gukoreshwa nk'intangiriro yo gutegura neocuproine, ikoreshwa nk'ireagent yo gusesengura mu kumenya umuringa mu bipimo by'ibidukikije hakoreshejwe tekiniki ya spectrophotometric.
Nyamara umuti nk'uwo ufite uburyo butandukanye cyane bwo kuvura. Vuba aha, Eribulin yemerewe kugurishwa n'Ikigo cy'Igihugu gishinzwe Ibikoresho by'Ubuvuzi (NMPA) cyo mu gihugu cyanjye mu kuvura abarwayi ba kanseri y'ibere basubira inyuma cyangwa banduye, bakaba barahawe nibura imiti ibiri ya chimiotherapie (harimo anthracyclines na taxans) mu bihe byashize. Yazanye uburyo bushya bwo kuvura kanseri y'ibere mu Bushinwa, kandi inazana ubundi buryo bwo kuvura abarwayi.
Eribulin ni umuti ubuza tubulin kudakoresha taxane. Bitandukanye n'imiti ibuza taxane na vinblastine tubulin, Eribulin ifite uburyo bwihariye bwo gukora, butuma Eribulin ikomeza kugira akamaro ku barwayi nyuma yo kudakoresha imiti; Eribulin kandi ifite ingaruka zitarimo uburozi, harimo kuvugurura imitsi, kongera urujya n'uruza rw'indi miti mu bidukikije bya kanseri, guhuza indi miti, no gusubiza inyuma uturemangingo twa kanseri. Impinduka ya epidermal-mesenchymal n'ibindi.
Kuva ku ikorwa ry’ibintu byose bya halichondrin B, ikoreshwa ry’ibintu bishya by’umuringa nk’ibihuza, kugeza ku ihinduka ry’imiterere ya Eribulin, kugeza ku musaruro w’inganda za Eribulin, abahanga mu bya siyansi bo mu mashuri makuru n’ibigo by’imiti bamaze imyaka irenga 20 bakora ubushakashatsi. Ibikoresho karemano bikomoka mu nyanja byahindutse imiti ishobora kuvura kanseri. Ubushakashatsi n’iterambere rya Eribulin ni uko ikintu gishya cy’umuringa ari ingenzi cyane nk’ikintu cy’ingenzi cya API yayo. Ikintu gishya cy’umuringa gifite uruhare runini nk’ikintu gihuza imiti n’igihuza mu gusukura ibikoresho byo mu rwego rwo hejuru.
Imiterere ya molekile ya Eribulin igizwe n'ibice 19 bya chiral, kandi intambwe zo gukora ingano zigera ku ntambwe 62. Kugeza ubu, Eribulin iracyafatwa n'inganda nk'umuti ugoye cyane utari peptide ukorwa n'ikorwa ry'ibinyabutabire by'umwimerere, kandi ishobora kwitwa Mount Everest mu nganda zikora ingano y'ibinyabutabire.
Urutonde rwa Eribulin rwagenze neza rugaragaza intambwe nshya inganda zikora imiti zishobora kugeraho mu gukora imiti no mu nganda. Bizana kandi ibitekerezo byinshi byo gusuzuma no kuvura ndetse n'amahitamo ku baganga b'Abashinwa. Birifuzwa ko mu gihe kizaza, umuti mushya wa Eribulin uvura kanseri y'ibere ushobora kuzana icyizere gishya ku barwayi ba kanseri y'ibere.
Igihe cyo kohereza: Mutarama-01-2021