Mirabegron CAS: 223673-61-8 Umukozi Ukora

Mirabegron ni umuti uvura indwara ya β3-adrenoceptor agonist mu kanwa, ubu uri gukorwa na Astellas Pharma, ugamije kuvura uruhago rukora cyane (OAB). Uyu muti ni umuti urwanya nanomolar EC50 urwanya isuzuma rya β3-AR ry’abantu, ukagira ubushobozi bwo guhitamo neza kurusha b1 na β2-AR. Mirabegron igaragaza uburyo bushya bwo kwibanda kuri β3-AR kugira ngo uruhago ruruhuke kugira ngo rufashe mu guhangana n’ibimenyetso bya OAB nko kwiyongera k’ubushyuhe bw’inkari n’inshuro nyinshi ndetse no kudakora neza kw’ubushyuhe. Ariko, mirabegron ni umuti ugabanya ubushyuhe bwa cytochrome P450 2D6, kandi utera impungenge ku mikoranire y’imiti n’imiti hamwe no gufata izindi ngingo za cytochrome P450 2D6.