Linezolide CAS: 165800-03-3

Linezolid ikoreshwa cyane mu buvuzi mu kuvura indwara zikomeye za bagiteri za Gram-positive zirwanya izindi antibiyotike. Ikunze kugurwa ku ndwara z’uruhu n’ingingo zoroshye, umusonga, bagiteri, n’indwara z’amagufwa ziterwa na MRSA, VRE, n’izindi ndwara zirwanya imiti myinshi. Ubushobozi bwa Linezolid bwo kwibasira izi ndwara zigoye kuvura butuma iba umuti w’ingenzi mu kuvura indwara zikomeye. Mu bitaro, linezolid ikunze gukoreshwa mu kuvura indwara za nosocomial na pneumonia ifitanye isano n’ubuvuzi bitewe n’imikorere yayo yagutse n’umutekano mwiza. Imiti yayo ikoreshwa mu kanwa yemerera kuvura indwara zimwe na zimwe hanze, iha abarwayi uburyo bwiza bwo kuvura indwara za bagiteri. Byongeye kandi, linezolid ikoreshwa mu kuvura igituntu n’izindi ndwara za mycobacterial nk’igice cy’imiti ivanze. Uburyo bwayo bwihariye bwo gukora no kwinjira neza mu ngingo bituma iba inyongera y’agaciro ku bikoresho byo kuvura igituntu kidakira imiti n’indwara za mycobacterial zidashobora kuvura igituntu. Mu bushakashatsi, linezolid ikoreshwa nk'urugero rw’ibanze mu gupima ubushobozi bwo kurwanya mikorobe kugira ngo hamenyekane uburyo bagiteri zishobora kuvura iyi antibiyotike. Mu kugena urugero ruto rw’umuti ubuza iyi ndwara (MIC) (Minimum inhibitory concentration) rwa linezolid mu kurwanya bagiteri runaka, abashakashatsi bashobora kuyobora ingamba zikwiye zo kuvura no kugenzura uburyo bwo kuyirwanya. Muri rusange, linezolid igira uruhare runini mu gucunga indwara zandura za bagiteri za Gram-positive, iha abaganga uburyo bukomeye kandi bwizewe bwo kuvura indwara zandurira mu miti. Kuba ifite ubushobozi, kwihanganira no gukoresha uburyo butandukanye bituma iba ingenzi cyane mu kurwanya indwara zandura, cyane cyane iziterwa na bagiteri zirwanya imiti myinshi.