Geldanamycin CAS: 30562-34-6

Nubwo geldanamycin yagaragaje imikorere yo kurwanya kanseri mu bushakashatsi bwa laboratwari, ikoreshwa ryayo mu buvuzi ni rike bitewe n'imbogamizi zijyanye n'uburozi n'ihindagurika ryayo. Ubushakashatsi burakomeje kugira ngo hakorwe ibikomoka kuri geldanamycin hamwe n'ibindi bigereranywa na geldanamycin bifite imiterere myiza y'imiti ndetse n'ingaruka mbi zishobora kugabanuka ku buryo ishobora gukoreshwa mu kuvura. Mu igerageza, geldanamycin n'ibikomoka kuri yo byakoreweho ubushakashatsi ku bushobozi bwayo bwo kubuza imikorere ya Hsp90, bigatuma poroteyine z'abakiriya zitera kwangirika no kubaho kw'uturemangingo twa kanseri zikura. Ubu buryo butuma geldanamycin iba umukandida mwiza wo kuvura kanseri, cyane cyane muri kanseri zishingiye ku nzira zigenzurwa na Hsp90. Igeragezwa ry'ubuvuzi rigamije imikorere n'umutekano w'ibikomoka kuri geldanamycin ku barwayi ba kanseri ririmo gukorwa kugira ngo hasuzumwe ubushobozi bwabyo nk'imiti irwanya kanseri. Ubu bushakashatsi bugamije gusuzuma inyungu z'umuti, uburyo bwiza bwo gutanga imiti, igipimo cy'ubutabazi, n'ingaruka mbi zijyanye na wo kugira ngo hamenyekane akamaro kawo mu buvuzi mu buvuzi bwa kanseri. Ubufatanye hagati y'abashakashatsi, ibigo by'imiti, ibigo bigenzura, n'abatanga serivisi z'ubuvuzi ni ngombwa kugira ngo hatezwe imbere iterambere ry'imiti ishingiye kuri geldanamycin no kuzana ubuvuzi bushya bwo kurwanya kanseri ku barwayi babukeneye. Iperereza rikomeje ku miterere y’imiti n’ingaruka z’ubuvuzi by’ibikomoka kuri geldanamycin ritanga icyizere cyo kunoza ingamba n’umusaruro mu kuvura kanseri mu gihe kizaza.