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2-Aside Hydroxyisonicotine CAS: 90-33-5
2-Aside Hydroxyisonicotinic ni ikintu gikomoka kuri aside isonicotinic, kirangwa no kuba hari itsinda rya hydroxyl ku mwanya wa kabiri w'impeta ya pyridine. Iki kintu kigaragaza ibikorwa bitandukanye bya biyoloji, harimo n'ubushobozi bwo kurwanya bagiteri n'ububyimbirwe. Kuba gifite imiterere isa n'indi aside nicotinic bituma kiba intego ishimishije yo guteza imbere imiti. Abashakashatsi bagiye bashakisha uburyo ikoreshwa mu buvuzi, cyane cyane mu kuvura indwara zitandukanye. Iki kintu gikora nk'inkingi yo gukora molekile zikomeye kandi cyakuruye ibitekerezo mu bijyanye no gukora organic synthesis no gukora ubushakashatsi ku miti.
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Methyl 2-aminopyridine-4-carboxylate CAS: 6937-03-7
Methyl 2-aminopyridine-4-carboxylate ni pyridine ikomoka kuri pyridine irimo itsinda rya amino riri ku mwanya wa 2 na ester ya carboxylate iri ku mwanya wa 4, hamwe na methyl iri ku mwanya wa aside carboxylic. Iki kinyabutabire gishishikajwe n'ubutabire bw'imiti bitewe n'ibikorwa byacyo bya biology, birimo ubushobozi bwo kurwanya mikorobe no kurwanya ububyimbirwe. Imiterere yihariye y'amatsinda mato yongera ubushobozi bwayo bwo gukora no gukoresha nk'inkingi ikomeye mu guhuza organic. Ubushakashatsi bukomeje gusuzuma ikoreshwa ryayo mu guteza imbere imiti n'izindi nzego, bigaragaza akamaro kayo mu rwego rwa heterocyclic chemistry.
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Tofacitinib Citrate CAS: 540737-29-9
Tofacitinib citrate ni umuti ubuza Janus kinase (JAK) ukoreshwa cyane cyane mu kuvura rubagimpande, rubagimpande y'amagufwa, na colitis y'ibisebe. Ikora mu gukumira mu buryo bwihariye enzymes za JAK1 na JAK3, zigira uruhare runini mu nzira z'ibimenyetso bya cytokine zitandukanye zigira uruhare mu mikorere y'ububyimbirwe. Hamwe na formula ya molekile C16H20N6O5S·C6H8O7, tofacitinib citrate yagaragaje ko ifite akamaro mu kugabanya ububyimbirwe no kunoza ubuzima bw'umurwayi. Yemejwe ko ikoreshwa mu buvuzi mu bihugu byinshi, ubushakashatsi bukomeje bugamije gusuzuma uburyo bwo kuvura, umutekano, n'ingaruka z'igihe kirekire mu ndwara zitandukanye ziterwa n'ubudahangarwa bw'umubiri.
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Cyclen CAS: 294-90-6
Cyclen, cyangwa 1,4,7,10-tetraazacyclododecane, ni imvange ya polyamine izwi cyane kubera imiterere yayo yihariye y’uruziga irimo atome enye za azote zikubiye mu ruziga rufite ibice cumi na bibiri. Hamwe na formula ya molekile C8H16N4, cyclen ikora nk'ingenzi muri shimi ihuza ibintu bitewe n'ubushobozi bwayo bwo gukora complexes zihamye hamwe n'ibyuma bihindura ibintu. Imiterere yayo yo gucenga ituma igira agaciro mu bikorwa bitandukanye, harimo shimi ivura, shimi ikoresha radiopharmaceuticals, na shimi ikoresha supramolecular. Ubushakashatsi buri gukorwa busesengura ubushobozi bwa cyclen mu gutanga imiti no guteza imbere ibikoresho byifashishwa mu gufata amashusho, bushimangira akamaro kayo mu bumenyi bw'ibanze n'ubukoreshwa.
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![4,4-dimethyl-3,5,8-trioxabicyclo[5.1.0]octane CAS:57280-22-5](https://cdn.globalso.com/xindaobiotech/8NS8DBIRAVXN0VCLT317.png)
4,4-dimethyl-3,5,8-trioxabicyclo[5.1.0]octane CAS:57280-22-5
4,4-Dimethyl-3,5,8-trioxabicyclo [5.1.0] octane ni organic compound irangwa n'imiterere yayo yihariye irimo ether linkages ebyiri na atome eshatu za ogisijeni mu buryo bwa bicyclic. Hamwe na formula ya molekile C10H16O3, iyi compound igaragaza imiterere ishimishije ya shimi bitewe n'uko hari amatsinda ya methyl ndetse n'imikorere ya ether. Imiterere yayo ya bicyclic igira uruhare mu gutuza no gukora neza, bigatuma ishobora gukoreshwa mu bikorwa bitandukanye muri chemistry ya synthetic organic. Ubushakashatsi busesengura ikoreshwa ryayo mu guhuza molekile zikomeye n'ubushobozi bwayo nk'inkingi y'ubwubatsi mu bumenyi bw'imiti n'ibikoresho.
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![4-Chloro-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine CAS:479633-63-1](https://cdn.globalso.com/xindaobiotech/VMLV8UWXAZ0XBLS6M290.png)
4-Chloro-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine CAS:479633-63-1
4-Chloro-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine ni ikintu cy’ubukorano kizwi cyane kubera ubushobozi bwacyo mu by’imiti. Gifite imiterere yihariye irimo inkingi ya pyrrolopyrimidine, chloro substituent, n’igice cya sulfonyl gifitanye isano n’itsinda rya para-methylphenyl. Iyi miterere y’imiterere ishobora kugira uruhare mu bikorwa byayo bya binyabuzima, bigatuma iba ikenewe mu bushakashatsi mu bice nka kanseri cyangwa ububyimbirwe. Ubushakashatsi burimo gukorwa kugira ngo hasuzumwe uburyo ikora, imikorere yayo, n’umutekano wayo, hagamijwe kumenya uburyo ishobora gukoreshwa mu kuvura indwara zitandukanye.
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3-Pyridinesulfonyl chloride CAS: 16133-25-8
3-Pyridinesulfonyl chloride ni ikintu cy'ingenzi mu bimera gifite formula ya molekile C6H6ClN O2S. Ni sulfonyl chloride ikomoka kuri pyridine, ifite itsinda ry’imikorere ya sulfonyl chloride rifatanye n’umwanya wa gatatu w’impeta ya pyridine. Iki kintu gikoreshwa cyane cyane mu guhuza ibimera nk'ikintu gifasha mu kwinjiza amatsinda ya sulfonyl mu bice bitandukanye. Uburyo ikora buyifasha kugira uruhare mu bikorwa byo gusimbuza ibintu mu buryo bwa nucleophilic, bigatuma igira akamaro mu gukora sulfonamides n’izindi molekyuli zikora. Byongeye kandi, 3-pyridinesulfonyl chloride ishobora gukoreshwa mu miti no mu binyabutabire by’ubuhinzi.
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2-Acide Aminoisonicotinic CAS: 13362-28-2
2-Aminoisonicotinic acid ni pyridine derivative, cyane cyane isomer ya aside nicotinic, irangwa no kuba hari itsinda rya amino ku mwanya wa 2 w'imiterere ya aside isonicotinic. Hamwe na formula ya molekile C6H6N2O2, iyi mvange igaragaza imiterere ishimishije ya shimi kandi yakuruye umwihariko mu buvuzi bw'imiti kubera ibikorwa byayo bya biology, harimo n'ingaruka za antimicrobial na anti-inflammatory. Imikorere ya aside amino na carboxylic ituma habaho impinduka zitandukanye za shimi, bigatuma iba urwego rw'agaciro mu guhuza organic. Ubushakashatsi buri gukorwa busesengura ubushobozi bwayo bwo kuvura, bugaragaza akamaro kayo mu iterambere ry'imiti n'izindi porogaramu.
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2-Amino-4-cyanopyridine CAS:42182-27-4
2-Amino-4-cyanopyridine ni ubwoko bwa pyridine burangwa n'itsinda rya amino riri ku mwanya wa 2 n'itsinda rya cyano riri ku mwanya wa 4 w'impeta ya pyridine. Hamwe na formula ya molekile C6H4N4, iki kinyabutabire kigaragaza imiterere itangaje ya shimi n'ibikorwa bishobora gukorwa na biyoloji. Cyakorewe ubushakashatsi ku ikoreshwa ryacyo mu buvuzi, cyane cyane mu guteza imbere imiti bitewe n'ingaruka zacyo zishobora gutera bagiteri, imiti yica udukoko, n'imiti irwanya ububyimbirwe. Kuba hari amatsinda yombi akora byongera ubushobozi bwayo bwo gukora, bigatuma iba urwego rw'agaciro mu guhuza ibinyabuzima. Ubushakashatsi bukomeje gusuzuma uburyo ikora mu nzego zitandukanye zirimo imiti n'ibinyabutabire by'ubuhinzi.
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2-(4-Hydroxyphenyl)-4-methyl-5-thiazolecarboxylic aside, ethyl ester, hydrochloride (1:1) CAS:399017-10-8
2-(4-Hydroxyphenyl)-4-methyl-5-thiazole aside carboxylic, ethyl ester, hydrochloride (1:1) ni ikintu kiva muri thiazole, kirangwa n'imiterere yayo yihariye irimo itsinda rya hydroxyl, itsinda rya methyl, na ethyl ester. Iki kintu cyakunzwe cyane mu buvuzi bitewe n'ibikorwa byacyo bya biology, nko kurwanya ububyimbirwe no kurwanya mikorobe. Ubwoko bw'umunyu wa hydrochloride bwongera ubushobozi bwo gushonga no kugumana imbaraga, byoroshya ikoreshwa ryawo mu miti. Ubushakashatsi bukomeje gusuzuma imikorere yawo mu buryo butandukanye bwo kuvura, bituma uba umukandida w'ingirakamaro mu bushakashatsi burambuye mu guteza imbere imiti no kunoza imikorere y'imiti.
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3-Methyl-4-nitropyridine N-Oxyde CAS: 1074-98-2
3-Methyl-4-nitropyridine N-oxide ni pyridine ikomoka kuri pyridine irangwa n'itsinda rya methyl riri ku mwanya wa 3 n'itsinda rya nitro riri ku mwanya wa 4 w'impeta ya pyridine, hamwe n'itsinda rikora rya N-oxide. Iki kinyabutabire kigaragaza imiterere igaragara ya shimi n'ibikorwa bya biyoloji, bigatuma gishishikazwa n'inzego zitandukanye nko mu buvuzi n'ibikomoka ku buhinzi. Kuba hari amatsinda ya nitro na N-oxide bishobora kongera uburyo ikoreshwa n'imikorere yayo mu buvuzi bw'ibinyabutabire. Ubushakashatsi bukomeje gusuzuma akamaro k'iki kinyabutabire mu kuvumbura imiti n'izindi porogaramu, berekana akamaro kacyo mu buvuzi bw'ibinyabuzima bwa none.
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(1R,2R)-N-Methylsulfonyl-1,2-diphenylethanediamine CAS:511534-44-4
(1R,2R)-N-Methylsulfonyl-1,2-diphenylethanediamine ni imvange y'ingenzi ya chiral irimo itsinda ry'imikorere ya sulfonamide n'umugongo wa diphenylethylene. Hamwe na formula ya molekile C16H20N2O2S, iyi mvange igira uruhare runini mu guhuza no gukora catalysis idafite ingano bitewe n'ubushobozi bwayo bwo gukora ibidukikije bya chiral bihamye. Imiterere yayo yihariye ituma habaho imikorere idasanzwe, bigatuma igira akamaro mu iterambere ry'imiti n'ibinyabutabire by'ubuhinzi. Ubushakashatsi buri gukorwa busesengura ikoreshwa ryayo mu guhuza stereoselective, bugaragaza ubushobozi bwayo nk'umusemburo mu bijyanye na shimi ya organometallic no kwagura akamaro kayo mu guhuza organic muri iki gihe.
