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Adenosine CAS: 58-61-7
Adenosine ni nucleoside igizwe na adenine na ribose, igira uruhare runini mu mikorere y'uturemangingo. Ikora nk'inkingi y'ibanze y'ubwubatsi bwa adenosine triphosphate (ATP), ifaranga ry'ingenzi mu mikorere y'ibinyabuzima. Uretse imirimo yayo ijyanye n'ingufu, adenosine igira uruhare mu bikorwa bitandukanye by'umubiri, harimo kohereza uturemangingo tw'ubwonko, kwaguka kw'imitsi, no kugenzura imikorere y'ibitotsi n'ibitotsi. Ikora ku byuma byihariye bifasha mu gutera umutima no gutembera kw'amaraso. Mu buvuzi, adenosine ikoreshwa mu buvuzi, cyane cyane mu kuvura indwara zimwe na zimwe zifata umutima. Inshingano zayo nyinshi zigaragaza akamaro ka adenosine haba mu buzima no mu ndwara.
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Uridine 5-monophosphate, umunyu wa disodium CAS: 3387-36-8
Uridine 5-monophosphate, umunyu wa disodium (UMP) ni nucleotide igira uruhare runini mu mikorere y’uturemangingo no mu gukora RNA. UMP igizwe na pyrimidine base uracil, isukari ya ribose, n'itsinda rya phosphate, ni ingenzi mu mikorere itandukanye ya biyoloji, harimo no gukora aside nucleic no kugenzura inzira za metabolisme. Ubwoko bwa disodium umunyu wongera ubushobozi bwo gushonga no kudahungabana mu bisubizo by'amazi, bigatuma ikoreshwa mu bushakashatsi bwa laboratwari no mu buvuzi. UMP yakunzwe cyane kubera ubushobozi bwayo bwo kurinda ubwonko no kongera ubushobozi bwo gutekereza, ndetse n'uruhare rwayo mu guteza imbere ubuzima bw'uturemangingo muri rusange.
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Cytidine 5′- (phosphate ya disodium) CAS: 6757-06-8
Cytidine 5′- (disodium phosphate) ni igikoresho cya nucleotide kigizwe na pyrimidine base cytosine, isukari ya ribose, n'itsinda rya phosphate. Iki kintu gikora uruhare runini mu mikorere itandukanye ya biochemical, harimo gukora RNA, inzira zo kugenzura, no gutanga ibimenyetso ku turemangingo. Ubwoko bw'umunyu wa disodium bwongera ubushobozi bwo gushonga no kudahungabana mu miterere y'umubiri, bigatuma ukoreshwa mu bushakashatsi bwo muri laboratwari no mu buryo bushobora gukoreshwa mu kuvura. Cytidine 5′- (disodium phosphate) yashishikajwe no kugira uruhare mu mikorere ya aside nucleic hamwe n'inyungu zayo mu kongera imikorere y'ubwenge no gushyigikira ubuzima bw'uturemangingo.
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5-Azacytidine CAS: 320-67-2
5-Azacytidine ni cytidine ikoze mu buryo bwa nucleoside imeze nk'iya cytidine irimo atome ya azote iri mu mwanya wa 5 w'impeta ya pyrimidine, igasimbura atome ya karuboni. Iyi mpinduka itanga imiterere yihariye y'imiti, ituma iba ikintu cy'ingenzi mu buvuzi bwa molekile no kuvura kanseri. Nk'umuti ukomeye wo gukumira ADN methyltransferase, 5-azacytidine ishobora kongera gukora gene zaburiwe irengero binyuze mu guhindura imiterere ya ADN methylation, bityo ikagira ingaruka ku mikorere ya gene. Mbere na mbere yakozwe kugira ngo ivure kanseri y'amaraso, 5-azacytidine yibanzweho kubera uburyo ishobora gukoreshwa mu kuvura kanseri, ubuvuzi bwo kuvugurura, no mu bushakashatsi bwibanda ku ndwara zitandukanye zirangwa no kugenzura gene mu buryo budasanzwe.
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2′-Fluoro-2′-deoxyuridine CAS:784-71-4
2′-Fluoro-2′-deoxyuridine (FdU) ni imiterere ya nucleoside ya deoxyuridine, aho atome ya hydrogen iri ku mwanya wa 2′ w'isukari ya ribose isimburwa na atome ya fluorine. Uku guhinduka kongera ubushobozi bwo kugumana ubuzima n'imikorere y'ibinyabutabire, bigatuma igira akamaro mu bushakashatsi ku binyabuzima no mu mikorere yo kuvura. FdU izwi cyane cyane kubera uruhare rwayo nk'umuti urwanya kanseri no kurwanya virusi, kuko ishobora kubangamira imikorere ya ADN no kubuza ikwirakwira rya virusi zimwe na zimwe n'uturemangingo twa kanseri. Imiterere yayo yihariye ituma iba igikoresho gikomeye mu iterambere ry'ubuvuzi bwihariye n'ubushakashatsi ku binyabuzima bya molekile.
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![4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one CAS:10212-20-1](https://cdn.globalso.com/xindaobiotech/8NS8DBIRAVXN0VCLT260.png)
4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one CAS:10212-20-1
4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one ni analoge y’uturemangingo tw’ingirabuzimafatizo ifite ishingiro rya pyrimidine rifatanye n’isukari ya ribose yahinduwe. Kuba hari atome ya fluorine n’amatsinda ya hydroxyl mu miterere yayo byongera imiterere yayo ya biochemical, bigatuma iba umukandida ushimishije mu bushakashatsi ku mikorobe no kurwanya kanseri. Iki kinyabutabire gishobora gukoreshwa mu buvuzi, cyane cyane nk'umuti uvura wibanda ku ikorwa rya aside nucleic n'inzira za metabolism mu binyabuzima bitera indwara. Imiterere yacyo yihariye ituma habaho imikoranire myiza n’ibintu bifitanye isano na ADN na RNA.
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1,3,5-tri-O-benzoyl-alpha-D-ribofuranose CAS:22224-41-5
1,3,5-Tri-O-benzoyl-alpha-D-ribofuranose ni ubwoko bwa ribose bwahinduwe mu buryo bwa shimi, bufite amatsinda atatu ya benzoyloxy afatanye n'imyanya ya 1, 3, na 5 y'imiterere ya ribofuranose. Uku guhinduka kongera ubushobozi bwayo bwo gushonga no kudahungabana, bituma igira akamaro mu bikorwa bitandukanye byo mu buhanga mu buhanga mu buhanga mu buhanga mu buhanga mu buhanga mu buhanga mu buhanga mu buhanga mu buhanga mu buhanga. Nk'ikintu kirinzwe na ribose, ikora nk'igice cy'ingenzi mu gukora nucleosides na nucleotides, ibice by'ingenzi bya RNA na ADN. Imiterere yayo yihariye ituma 1,3,5-tri-O-benzoyl-alpha-D-ribofuranose igira akamaro ku bashakashatsi bashaka gukora imiti mishya n'ibikoresho mu buhanga mu buhanga mu buhanga mu buhanga mu buhanga mu buhanga mu buhanga mu buhanga mu buhanga mu buhanga mu buhanga mu buhanga mu buhanga mu buhanga mu buhanga mu buhanga mu buhanga mu buhanga mu buhanga mu buhanga mu buhanga mu buhanga mu buhanga mu buhanga mu buhanga mu buhanga mu buhanga mu buhanga mu buhanga.
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2′-O-methyluridine CAS:2140-76-3
2′-O-Methyluridine ni nucleoside isanzwe aho itsinda rya methyl rifatanye na atome ya ogisijeni iri mu mwanya wa 2′ w'isukari ya ribose muri uridine. Uku guhinduka kongera ubushobozi bwo gutuza no gukora neza kwa molekile za RNA, bigatuma iba igice cy'ingenzi mu mikorere itandukanye ya biyoloji. 2′-O-Methyluridine igira uruhare runini mu miterere n'imikorere ya aside ribonucleic (RNA), harimo na RNA y'intumwa (mRNA) na RNA yo kohereza (tRNA). Kuba ihari bishobora kugira ingaruka ku ituza rya RNA, imikorere myiza yo guhindura, no ku mikoranire na poroteyine n'izindi aside nucleic, bigatuma iba ikintu cy'ingenzi mu kwiga biology ya molekile no kuvura.
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adenosine 5′-monophosphate sodium* ikomoka ku musemburo CAS:4578-31-8
Adenosine 5′-monophosphate sodium (AMP) ni nucleotide ikomoka kuri adenosine igira uruhare runini mu mikorere y’uturemangingo. AMP ni ingenzi mu mikorere itandukanye ya biyoloji, harimo kohereza ingufu, gutanga ibimenyetso, no kuba imbarutso yo gukora ATP n’izindi nucleotide. Ubwoko bw’umunyu wa sodium wa AMP bushobora kuva ku musemburo, ukungahaye kuri nucleotide bitewe n’inzira zawo zikora za metabolisme. Iki kintu gikunze gukoreshwa muri biochimie na farumasi nk'ikintu gihindura imikorere ya biochemical, inyongeramusaruro ku biribwa, n’inyongeramusaruro ku mirire, bitewe n’inyungu zishobora kubaho ku buzima n’ikoreshwa mu guteza imbere metabolisme y’ingufu.
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2′-Deoxycytidine CAS:951-77-9
2′-Deoxycytidine ni nucleoside igizwe n'isukari ya deoxyribose na cytosine, itandukaniye ku kutagira itsinda rya hydroxyl ku mwanya wa 2′ wa ribose. Iri hinduka rituma iba igice cy'ingenzi cya ADN, aho ihuzwa na guanine mu gihe cyo guhuza ibice by'ibanze. 2′-Deoxycytidine igira uruhare runini mu mikorere y'uturemangingo no mu gukora ADN, ikaba inkingi y'ubwubatsi bwa deoxycytidine triphosphate (dCTP), ikaba ari ingenzi mu kongera no gusana ADN. Byongeye kandi, iyi nucleoside ifite ingaruka zikomeye mu bushakashatsi ku binyabuzima bya molekile, kuvura kanseri, no ku ngamba zo kurwanya indwara ziterwa na virusi, bigaragaza akamaro kayo mu bushakashatsi bw'ibanze no mu buvuzi.
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2,2′-cyclouridine CAS: 3736-77-4
2,2′-Cyclouridine ni igikoresho cya bicyclic nucleoside derivative ya uridine, kirangwa no gukora imiterere yihariye y’uruziga ikubiyemo imyanya ya 2′ na 2” y’igice cya ribose. Uku guhinduka kw’imiterere gutanga imiterere yihariye ya biochemical igira ingaruka ku ituze ryayo n’imikorere yayo ya biological. 2,2′-Cyclouridine yashishikajwe n’ubumenyi bw’ibinyabuzima n’imiti bitewe n’uko ishobora gukoreshwa nk’umuti urwanya virusi ndetse no mu bushakashatsi bwa RNA. Ubushobozi bwayo bwo guhindura imikoranire ya aside nucleic butuma iba igikoresho cy’agaciro mu kwiga isano iri hagati y’imiterere ya RNA n’imikorere yayo, bishobora gutuma habaho iterambere mu ngamba zo kuvura zigamije kwandura virusi n’indwara zikomoka ku maraso.
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2-Aminoadenosine CAS: 2096-10-8
2-Aminoadenosine ni ikintu gikomoka kuri adenosine mu buryo busanzwe, kirangwa no kuba hari itsinda ry’amine riri ku mwanya wa 2 w’isukari ya ribose. Iri hinduka rihindura cyane imiterere n’imikorere yabyo ya biokemike, rigatuma iba molekile y’ingenzi mu mikorere itandukanye ya fiziki. 2-Aminoadenosine igira uruhare mu gutanga ibimenyetso ku ngirabuzimafatizo, imikorere y’umubiri, n’inzira zigenga, harimo n’izijyanye n’ingufu zituma habaho ingufu no kohereza uturemangingo tw’ubwonko. Uburyo ishobora gukoreshwa mu kuvura bushobora kugera ku bintu byinshi, harimo n’ingirabuzimafatizo z’imitsi n’indwara z’umutima, aho ishobora kugira ingaruka ku buryo ngirabuzimafatizo zifatwa n’imihangayiko n’ibyago. Uko ubushakashatsi bukomeza, 2-aminoadenosine ifite icyizere cyo guteza imbere ibintu bishya bitanga ubuzima n’ibivura.
