dUMP, 2′-Deoxyuridine-5′-monophosphate, umunyu wa disodium CAS:42155-08-8

2′-Deoxyuridine-5′-monophosphate (dUMP) ni igikoresho cya nucleotide kigira uruhare mu gukora no gusana ADN. Ikora nk'intangiriro ya dTTP (deoxythymidine triphosphate), ikaba ari inkingi y'ingenzi mu gukora ADN. dUMP kandi ni ingenzi mu gikorwa cyo gukora thymidylate, aho ihindurwamo dTMP (deoxythymidine monophosphate) na enzyme thymidylate synthase. Iri hinduka ni ingenzi mu kubungabunga imiterere ya nucleotide n'ubuziranenge bwa ADN mu turemangingo.

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Guhuza ADN: dUMP ikora nk'intangiriro ya deoxythymidine triphosphate (dTTP), ikaba ari ingenzi mu kongera gukora ADN. Guhindura dUMP muri dTMP ni intambwe y'ingenzi mu gukora nucleotides za thymidine, zikaba ingenzi cyane mu kongera gukora neza kw'ibintu bigize imiterere y'uturemangingo mu gihe cyo kwigabanyamo ibice.

Uburyo bwo gukora imikorere ya thymidylate: dUMP ni substrate ya enzyme thymidylate synthase, ituma dUMP ihinduka dTMP. Iyi gahunda ni ingenzi mu kubungabunga uburinganire bukwiye bwa nucleotide mu turemangingo no kwemeza ko ADN ikomeza kuba inyangamugayo.

Intego y'umuti urwanya kanseri: Thymidylate synthase, enzyme igira uruhare mu guhindura dUMP muri dTMP, ni intego y'imiti imwe n'imwe irwanya kanseri. Kubuza thymidylate synthase bishobora kubangamira imikorere ya ADN no kwiyongera kw'uturemangingo, bigatuma ishobora kuba intego y'imiti ivura kanseri.

Igikoresho cy'Ubushakashatsi: dUMP ikoreshwa mu bushakashatsi bwa biochemical na molekile nk'igice cyo kwiga uburyo bwo gukora, gusana, no gutunganya ADN. Ikoreshwa kandi mu isuzuma rya enzyme kugira ngo isuzume imikorere ya thymidylate synthase n'ibindi bifitanye isano.

Gupakira ibicuruzwa:

Amakuru y'inyongera:

Imiterere	C9H14N2NaO8P
Isuzuma	99%
Isura	Ifu y'umweru
Nimero ya CAS	42155-08-8
Gupakira	Bito kandi byinshi
Igihe cyo Kubika	Imyaka 2
Ububiko	Bika ahantu hakonje kandi humutse
Icyemezo	ISO.