Candesartana Cilexetila CAS: 145040-37-5

Candesartan cilexetil ni prodrug yububasha bukomeye, bukora igihe kirekire, kandi bwatoranijwe bwa angiotensin II ubwoko bwa 1 reseptor AT1 antagonist, candesartan.Ihita yihuta kuri candesartan mugihe cyo kwinjiza gastrointestinal.Nyuma ya hydrolysis ya candesartan cilexetil kuri candesartan mugihe cyo kwinjiza gastrointestinal, candesartan yahisemo guhangana na angiotensin II kugirango ihuze reseptor ya angiotensin II reseptor subtype 1 AT1 mumitsi yoroshye yimitsi, ibuza angiotensin II yunganirwa na vasoconstriction no gutera vasodilatation.Byongeye kandi, antagonism ya AT1 muri glande ya adrenal ibuza angiotensin II-iterwa na synthesis ya aldosterone hamwe no gusohora na cortex ya adrenal;sodium n'amazi asohoka byiyongera, hakurikiraho kugabanuka kwa plasma n'umuvuduko w'amaraso.