Bz-His-OH CAS: 5354-94-9

Bz-His-OH ni igice cy'ingenzi mu gukora peptide, ikaba inkingi y'ingenzi mu kubaka peptide zifite imiterere yihariye n'imikorere. Itsinda ririnda benzyl rigenzura ko ibisigazwa bya histidine bitahinduka mu gihe cyo gukora peptide, bigatuma peptide iteranywa neza kandi igenzurwa. Iki kinyabutabire ni ingenzi mu gushushanya peptide zifite imiterere yihariye nko kunoza ubusugire, ubushobozi bwa pH, cyangwa guhuza ion mu byuma, bigatuma kiba igikoresho cy'ingenzi mu iterambere ry'imiti. Byongeye kandi, Bz-His-OH ikoreshwa mu gukora imiti ishingiye kuri peptide ifite ubushobozi bwo kuvura burushijeho kwiyongera bitewe n'imiterere yayo yihariye. Byongeye kandi, mu bushakashatsi bwa proteomics na biochemical, Bz-His-OH ikoresha mu kwiga ibikorwa bya enzyme, gukora ubushakashatsi ku miterere y'ibyuma, no gusesengura impinduka zishingiye kuri pH muri poroteyine. Imiterere yayo yihariye ituma abashakashatsi bashobora gusuzuma imiterere y'uturemangingo n'imikorere y'indwara, bigira uruhare mu iterambere mu gusobanukirwa ubuzima n'indwara. Uburyo iki kinyabutabire gihuzwa n'imiterere itandukanye y'igerageza bituma kiba igice cy'ingenzi mu gusesengura ingorane z'imikorere y'ibinyabuzima no guteza imbere uburyo bwo kuvura indwara zitandukanye. Muri make, Bz-His-OH ni igikoresho cy'agaciro ku bashakashatsi mu bijyanye no gukora peptide, guteza imbere imiti, n'ubushakashatsi ku binyabuzima, bitanga ubushobozi bwo guhindura peptide zifite imiterere yihariye no gusesengura uburyo bw'ibanze bw'imikorere y'ibinyabuzima, bityo bigatanga umusanzu mu iterambere mu buvuzi no mu ikoranabuhanga.