Boc-Trp-OSu CAS: 3392-11-8

Boc-Trp-OSu igira uruhare runini mu mikorere ya shimi ihuza ibinyabuzima, cyane cyane mu mikorere ya peptide na poroteyine kugira ngo ikoreshwe mu buryo bwihariye. Nk'ikinyabutabire cya NHS ester, byoroshya guhuza tryptophan ya Boc-protected na amines z'ibanze ziba muri aside amine, peptides, cyangwa poroteyine. Uku guhuza kw'ibice by'ingenzi byemerera guhindura neza ibisigazwa bya aside amine runaka mu gice cya peptide cyangwa N-terminus ya poroteyine, bigatuma amatsinda y'imikorere cyangwa ibirango bikoreshwa mu buryo butandukanye. Abashakashatsi n'abahanga mu bya shimi bakoresha Boc-Trp-OSu mu guteza imbere peptide conjugates mu bikorwa nko gutanga imiti yihariye, isuzuma ry'ubudahangarwa bw'umubiri, no gukora biomaterial. Mu guhuza peptides za Boc-Trp-OSu-modified na molecules cyangwa ubuso bugamije, bashobora gukora imiterere ya bioactive ishobora gukorana neza na receptors za cellule, antigens, cyangwa matrices ya biological. Byongeye kandi, Boc-Trp-OSu ikoreshwa mu gutegura peptide-protein conjugates mu gukora antibody-drug conjugates (ADCs) no gushyira ibirango kuri poroteyine mu gupima no gusuzuma. Uburyo bwo gukora Boc-Trp-OSu butuma iba igikoresho cy'ingenzi mu nzego zitandukanye nko mu binyabuzima by'ibinyabutabire, ikoranabuhanga rya biotechnology, n'ubumenyi bw'imiti. Kuba ihura na protocole za bioconjugation, reactivity nyinshi, no guhitamo bigira uruhare mu ikoreshwa ryayo mu nzego z'ubushakashatsi n'inganda. Byaba bikoreshwa mu bushakashatsi bw'ibanze cyangwa iterambere ry'ubuvuzi buhanitse, Boc-Trp-OSu ituma habaho peptide conjugates zihariye zigomba kuba ingenzi mu guteza imbere ubuvuzi bwihariye no gusuzuma molekile.