Boc-Nle-OH · DCHA CAS: 21947-32-0

Boc-Nle-OH·DCHA ikoreshwa cyane mu gukora peptide ikoze mu cyiciro gikomeye kugira ngo ikore peptide zakozwe ku giti cyazo zifite uruhererekane n'imikorere yihariye. Nk'uburyo burinzwe bwa norleucine, yemerera kwinjiza ibisigazwa bya norleucine mu ruhererekane rwa peptide rurimo gukura, ikarinda ingaruka mbi zitifuzwa kandi yemerera peptide zikomeye zifite imiterere yihariye. Mu bijyanye no guhuza ibinyabuzima n'ibinyabuzima, Boc-Nle-OH·DCHA ikora nk'inkingi ikomeye yo gukora peptide zikora ku mubiri, imashini zigaragaza ibirango, n'imiti ishingiye kuri peptide. Ikoreshwa ryayo ryemerera guhindura neza peptide na poroteyine, byorohereza iterambere rya molekile zikora neza zifite ubushobozi bwo guhagarara neza, ubushobozi bwo kwibanda ku ntego, cyangwa ubushobozi bwo gufata amashusho ku bikorwa bitandukanye bya siyansi. Byongeye kandi, mu kuvumbura imiti no guteza imbere ubuvuzi, Boc-Nle-OH·DCHA ikoreshwa mu gukora peptide conjugates na peptide zahinduwe zifite imiterere myiza ya pharmacokinetic n'ibikorwa bya biologique. Izi mpinduka zishobora kongera imikorere, guhitamo, no gutanga imiti ishingiye kuri peptide, bigatanga umusanzu mu iterambere mu buvuzi bunoze no mu buvuzi bugamije. Muri rusange, ubwizerwe bwa Boc-Nle-OH·DCHA mu gukora peptide no guhuza ibinyabuzima bituma iba igikoresho cy'ingenzi mu guteza imbere ubushakashatsi mu kuvumbura imiti, ibinyabuzima by'ibinyabutabire, na proteomics, bitanga amahirwe atandukanye yo guteza imbere uburyo bushya bwo gukoresha imiti.