4-Nitrophenyl Beta-D-glucuronide CAS: 10344-94-2

Kumenya imikorere ya β-glucuronidase: 4-NPBG ikunze gukoreshwa nk'igice cya chromogenic kugira ngo hamenyekane niba β-glucuronidase ihari kandi ikora mu bipimo bitandukanye by'ibinyabuzima. Iyi enzyme ica umugozi wa glycosidic wa 4-NPBG, igatanga 4-nitrophenol, ishobora gupimwa hakoreshejwe spectrophotometry.

Inyigo ku mikorere y'imiti: Kubera ko β-glucuronidase igira uruhare runini mu mikorere y'imiti n'ibinyabutabire, 4-NPBG ishobora gukoreshwa mu gusuzuma imikorere y'iyi enzyme mu inyigo ku mikorere y'imiti. Ifasha mu gusobanukirwa ingano n'imikorere y'ibiganiro bya glucuronidation, ari ingenzi mu gutuma imiti ivamo kandi iboneka neza.

Ubushakashatsi ku burozi: Hari ibintu bimwe na bimwe bishobora guhindurwamo glucuronide conjugates. Bakoresheje 4-NPBG nk'igice cy'ingenzi, abashakashatsi bashobora gusuzuma imikorere ya β-glucuronidase mu ngingo zitandukanye cyangwa mu turemangingo kugira ngo basuzume uburozi bushobora guterwa n'ibintu cyangwa ingaruka mbi.

Isuzuma ry’indwara: Gupima imikorere ya β-glucuronidase hakoreshejwe 4-NPBG bishobora gukoreshwa mu buvuzi kugira ngo hamenyekane indwara zimwe na zimwe cyangwa indwara zimwe na zimwe. Ingano cyangwa imikorere idahwitse ya β-glucuronidase bishobora kugaragaza indwara zimwe na zimwe za genetiki, imikorere mibi y’umwijima, cyangwa kanseri.