4-Nitrophenyl Beta-D-glucuronide CAS: 10344-94-2

4-Nitrophenyl Beta-D-glucuronide ni imiti ivangwa no guhuza molekile ya glucose mu itsinda rya 4-nitrophenyl binyuze mu guhuza glycoside.Bikunze gukoreshwa nka substrate mubisubizo byimisemburo kugirango hamenyekane ahari n'ibikorwa bya β-glucuronidase, enzyme igira uruhare muri metabolism yibiyobyabwenge bitandukanye na xenobiotics mu nyamaswa z’inyamabere.Iyo β-glucuronidase ihari, ikuraho isano ya glycoside iri hagati ya glucose hamwe na 4-nitrophenyl, bivamo kurekura 4-nitropenol, ishobora kugaragara kuri spekitifotometometrike kuri 400-420 nm.Iyi reaction enzymatique itanga igipimo cyinshi cyibikorwa bya glucuronidase kandi ikoreshwa nkigikoresho cyo kuvumbura ibiyobyabwenge, ubushakashatsi bw’uburozi, no gusuzuma indwara.

Tegeka cyangwa usabe amagambo

Ibicuruzwa birambuye

Ibicuruzwa

Gushyira mu bikorwa n'ingaruka

Kumenya ibikorwa β-glucuronidase: 4-NPBG isanzwe ikoreshwa nka chromogenic substrate kugirango isuzume ahari n'ibikorwa bya β-glucuronidase mubitegererezo bitandukanye byibinyabuzima.Enzyme ikuraho glycosideque ya 4-NPBG, ikabyara 4-nitropenol, ishobora gupimwa hakoreshejwe spekitifotometometrie.

Ubushakashatsi bwibiyobyabwenge: Kubera ko β-glucuronidase igira uruhare runini muri metabolism yibiyobyabwenge na xenobiotics, 4-NPBG irashobora gukoreshwa mugusuzuma ibikorwa byiyi misemburo mubushakashatsi bwibiyobyabwenge.Ifasha mugusobanukirwa urugero na kinetics ya glucuronidation reaction, ningirakamaro mugukuraho ibiyobyabwenge na bioavailability.

Ubushakashatsi bwuburozi: Bimwe mubintu byuburozi birashobora guhindagurika kandi bigasohoka muburyo bwa glucuronide conjugate.Ukoresheje 4-NPBG nka substrate, abashakashatsi barashobora gusuzuma ibikorwa bya β-glucuronidase mubice bitandukanye cyangwa imirongo ya selile kugirango basuzume uburozi cyangwa ingaruka mbi ziterwa.

Kwipimisha kwa Clinical: Gupima ibikorwa β-glucuronidase ukoresheje 4-NPBG birashobora gukoreshwa mubitaro kugirango hamenyekane indwara cyangwa indwara zimwe na zimwe.Urwego rudasanzwe cyangwa ibikorwa bya β-glucuronidase birashobora kwerekana indwara zimwe na zimwe, imikorere mibi yumwijima, cyangwa kanseri.

Icyitegererezo cyibicuruzwa

Gupakira ibicuruzwa:

Amakuru yinyongera:

Ibigize	C12H13NO9
Suzuma	99%
Kugaragara	Ifu yera
URUBANZA No.	10344-94-2
Gupakira	Ntoya kandi nini
Ubuzima bwa Shelf	Imyaka 2
Ububiko	Ubike ahantu hakonje kandi humye
Icyemezo	ISO.