2,3,4,6-Tetra-O-acetyl-α-D-galactopyranosyl 2,2,2-trichloroacetimidate CAS: 86520-63-0

2,3,4,6-Tetra-O-acetyl-α-D-galactopyranosyl 2,2,2-trichloroacetimidate ni imiti ikoreshwa cyane muri chimie ya karubone ndetse na glycosylation.Nibikomoka kuri α-D-galactopyranose, ubwoko bwisukari, aho amatsinda ya hydroxyl kumyanya 2, 3, 4, na 6 yimpeta ya galactopyranose acetylated.Byongeye kandi, karubone ya anomeric (C1) yisukari irinzwe hamwe nitsinda rya trichloroacetimidate, bigatuma ikora electrophile ikomeye mugihe cya glycosylation.

Uru ruganda rukoreshwa kenshi nka glycosylating agent kugirango yinjize galaktose moieties muri molekile zitandukanye, nka proteyine, peptide, cyangwa molekile ntoya.Ibi birashobora kugerwaho mugukora iyi compound hamwe na nucleophile (urugero, hydroxyl matsinda kuri molekile yagenewe) mugihe gikwiye.Itsinda rya trichloroacetimidate ryorohereza guhuza galaktose ya molekile yagenewe, bikavamo gushiraho glycosidic.

Uru ruganda rusanzwe rukoreshwa muguhuza glycoconjugates, glycopeptides, na glycolipide.Itanga uburyo butandukanye kandi bunoze bwo guhindura molekile hamwe nibisigara bya galaktose, bishobora kuba ingirakamaro mubice bitandukanye, harimo ubushakashatsi bwibinyabuzima, uburyo bwo gutanga ibiyobyabwenge, cyangwa iterambere ryinkingo.

Tegeka cyangwa usabe amagambo

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Gushyira mu bikorwa n'ingaruka

Glycosylation: Ifumbire ikora hamwe na molekile zitandukanye zemera zirimo amatsinda ya hydroxyl, nka alcool cyangwa amine, kugirango habeho isano ya glycoside.Ibi bituma kwinjiza galactose kuri molekile yakira, bikavamo synthesis ya glycoconjugates, glycopeptides, cyangwa glycolipide.

Ubushakashatsi bwibinyabuzima n’ibinyabuzima: Urusange rufasha abashakashatsi kwiga imikorere y’ibinyabuzima n’imikoranire ya molekile irimo galaktose.Mu guhitamo galaktose kuri poroteyine, peptide, cyangwa izindi biomolecules, abashakashatsi barashobora gukora iperereza ku ruhare rwabo mu ngirabuzimafatizo, imikoranire ya reseptor-ligand, hamwe n’uburyo bw’indwara.

Sisitemu yo gutanga ibiyobyabwenge: Uru ruganda rushobora gukoreshwa muguhindura molekile yibiyobyabwenge hamwe nibisigara bya galaktose, byorohereza imiti igenewe ingirabuzimafatizo cyangwa selile.Galactose irashobora gukora nka ligand igamije, ikamenya reseptors yihariye igaragara hejuru ya selile, cyane cyane hepatocytes.Muguhuza galaktose kumiti, abashakashatsi barashobora kongera guhitamo no gukora neza mubuvuzi bugamije.

Iterambere ryinkingo: molekile zirimo galaktose zigira uruhare runini mubisubizo byubudahangarwa bw'umubiri, kuko bizwi n'amasomo ahari ingirabuzimafatizo.Muguhuza antigene hamwe na galactose moieties ukoresheje uru ruganda, abashakashatsi barashobora kongera ubudahangarwa bw'umubiri no guteza imbere inkingo nziza.

Synthesis ya chimique: Urusange rushobora gukoreshwa muburyo butandukanye bwa chimique aho bisabwa guhindura galactose.Ibi birimo gutegura ibyubaka karubone nziza, oligosaccharide, cyangwa glycomimetics, bishobora gukoreshwa cyane muri chimie miti cyangwa nkibikoresho byubushakashatsi.

Icyitegererezo cyibicuruzwa

Gupakira ibicuruzwa:

Amakuru yinyongera:

Ibigize	C16H20Cl3NO10
Suzuma	99%
Kugaragara	Ifu yera
URUBANZA No.	86520-63-0
Gupakira	Ntoya kandi nini
Ubuzima bwa Shelf	Imyaka 2
Ububiko	Ubike ahantu hakonje kandi humye
Icyemezo	ISO.