β-Nicotinamide Adenine Dinucleotide CAS: 53-84-9

NAD+ ifite akamaro kanini mu mikorere y’uturemangingo kandi yakuruye ubushake mu nzego nko gukora ubushakashatsi ku gusaza, metabolisme, n’ubuzima bw’uturemangingo. Nk’inyongeramusaruro, NAD+ igira uruhare mu bikorwa bya redox by’ingenzi mu gukora ingufu muri mitochondria, ishyigikira inzira nka glycolysis, cycle ya aside tricarboxylic, na phosphorylation ya oxidative. Byongeye kandi, NAD+ ikora nk'ishingiro ry’imisemburo nka sirtuines na PARPs, igira uruhare mu gusana ADN, kugenzura ishyirwa mu bikorwa rya gene, no mu nzira zo gusubiza stress ku turemangingo. Mu myaka ya vuba aha, ibintu bya NAD+, nka nicotinamide riboside (NR) na nicotinamide mononucleotide (NMN), byakunze kwitabwaho nk'inyongera zishobora gushyigikira urugero rwa NAD+ mu turemangingo. Ubushakashatsi bwerekana ko kubungabunga urugero rwiza rwa NAD+ bishobora kugira uruhare mu mitochondria biogenesis, homeostasis ya metabolisme, no kuramba. Kubera iyo mpamvu, ibintu bya NAD+ birimo gukorwaho ubushakashatsi ku bushobozi bwabyo bwo kugabanya igabanuka rifitanye isano n’izabukuru, gushyigikira gusaza neza, no gukemura ikibazo cy’ubusumbane mu metabolisme bifitanye isano n’indwara nk’umubyibuho ukabije na diyabete. Byongeye kandi, NAD+ ni ishami rishishikajwe cyane na siporo n'imikorere y'imyitozo ngororamubiri bitewe n'uruhare rwayo mu mikorere y'ingufu n'imikorere ya mitochondrial. Ubushakashatsi busesengura uburyo NAD+ ihindukamo mu bijyanye n'imikorere y'imyitozo ngororamubiri, kugarura imitsi, n'ubushobozi bwo kwihangana burakomeje, hamwe n'ingaruka zishobora kugira ku mikorere y'imikino ngororamubiri no kwihangana. Muri rusange, NAD+ n'ibiyibanjirije bigaragaza igice cy'ubushakashatsi bwa siyansi gifite ikoreshwa rishobora kuba rigizwe no gusaza, ubuzima bw'uturemangingo, imikorere y'imyitozo ngororamubiri, n'imikorere y'imyitozo ngororamubiri, bigaragaza imiterere migari kandi ihinduka y'ubushakashatsi n'akamaro gashobora kuba mu kuvura.